Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chandana Barat"'
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101293 (2014)
BACKGROUND: The ribosome, which acts as a platform for mRNA encoded polypeptide synthesis, is also capable of assisting in folding of polypeptide chains. The peptidyl transferase center (PTC) that catalyzes peptide bond formation resides in the domai
Externí odkaz:
https://doaj.org/article/1a3b6482332d4c779ad7947e150a11bc
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96425 (2014)
BACKGROUND: Molecular chaperones that support de novo folding of proteins under non stress condition are classified as chaperone 'foldases' that are distinct from chaperone' holdases' that provide high affinity binding platform for unfolded proteins
Externí odkaz:
https://doaj.org/article/0192f61e61af4094959bcf46db38068c
Publikováno v:
Protein & Peptide Letters. 29:993-1005
Background: Alzheimer’s disease (AD) is characterized by the aggregation of Tau protein and Amyloid-β peptides (Aβ 1-40 and Aβ 1-42). A loss of ribosomal population is also observed in the neurons in affected regions of AD. Our studies demonstra
Publikováno v:
The FEBS Journal. 288:1305-1324
Ribosome hibernation is a prominent cellular strategy to modulate protein synthesis during starvation and the stationary phase of bacterial cell growth. Translational suppression involves the formation of either factor-bound inactive 70S monomers or
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
The human tau is a microtubule-associated intrinsically unstructured protein that forms intraneuronal cytotoxic deposits in neurodegenerative diseases, like tauopathies. Recent studies indicate that in Alzheimer’s disease, ribosomal dysfunction mig
Publikováno v:
FEBS lettersReferences. 596(9)
Alzheimer's disease (AD) is characterized by the appearance of neurofibrillary tangles comprising of the Tau protein and aggregation of amyloid-β peptides (Aβ 1-40 and Aβ 1-42). A concomitant loss of the ribosomal population is also observed in AD
Publikováno v:
Letters in Applied Microbiology. 64:79-85
The ability of the ribosome to assist in folding of proteins both in vitro and in vivo is well documented and is a nontranslational function of the ribosome. The interaction of the unfolded protein with the peptidyl transferase centre (PTC) of the ba
Autor:
Bani K. Pathak, Chandana Barat, Biprashekhar Chakraborty, Jayati Sengupta, Senjuti Banerjee, Surojit Mondal
Publikováno v:
The FEBS journal. 284(22)
The ability of the ribosome to assist in the folding of proteins both in vitro and in vivo is well documented. The interaction of an unfolded protein with the peptidyltransferase center of the bacterial large ribosomal subunit is followed by release
Publikováno v:
Scientific Reports
An understanding of the mechanisms underlying protein aggregation and cytotoxicity of the protein aggregates is crucial in the prevention of several diseases in humans. Ribosome, the cellular protein synthesis machine is capable of acting as a protei
Publikováno v:
Biochemistry. 43:8191-8203
These studies were aimed at an initial characterization of the human vasopressin precursor and the evaluation of factors leading to misfolding by the pathological 87STOP mutation. This mutation deletes the precursor's glycosylated copeptin segment, w