Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Chandan Bhugra"'
Stability testing is a time-consuming activity that slows down the drug product development process, especially in early clinical development, as drug product is aged at defined conditions for defined periods of time. The typical ICH stability proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93161bd0ea7188bec28843308742b383
https://doi.org/10.1016/b978-0-12-802786-8.00008-5
https://doi.org/10.1016/b978-0-12-802786-8.00008-5
Autor:
Anjali Agrawal, Stan Altan, Steven W. Baertschi, Chandan Bhugra, Ricardo Borjas, John Campbell, Dana Carabillo, Juan Chen, Lilan H. Chen, Donald Clancy, Elise Clement, Stephen T. Colgan, David Curran, Gena Dalziel, Mayur Dudhedia, Sudharsan Dwaraknath, Anita L. Freed, Paul Gerst, Michael Hawley, Evan M. Hetrick, Cherokee S. Hoaglund Hyzer, Gordon Hutton, Madhuri Jerfy, Satish Kamath, Ammar Khawam, Todd Lewis, Hanlin Li, Julie Lippke, Bruce C. MacDonald, Llurellyn Malcolm, Keith Masse, Tony Mazzeo, Andrew P. Monahan, Ewa Nauka, Rachel Orr, Brian W. Pack, Jeegna Patel-Jones, Jackson D. Pellett, William R. Porter, Fenghe Qiu, Jeffrey C. Roberts, Samantha Rusk, Kevin O. Ryan, Kevin Ryan, Robert Schwabe, Garry Scrivens, Ashish Soman, Jon T. Swanson, Zhixin Jessica Tan, Martyn Ticehurst, Robert J. Timpano, Bryan S. Wicks, Zeena Williams, Chad N. Wolfe, Gavin Wood, Zufan Steven Wu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddf3d76a1a8cc8978d2bef65c0f977b9
https://doi.org/10.1016/b978-0-12-802786-8.09988-5
https://doi.org/10.1016/b978-0-12-802786-8.09988-5
Publikováno v:
Molecular pharmaceutics. 13(9)
API-polymer interactions, used to select the right polymeric matrix with an aim to stabilize an amorphous dispersion, are routinely studied using spectroscopic and/or calorimetric techniques (i.e., melting point depression). An alternate selection to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c54d8f1523ff90a6cd76dbe42e238
https://pubmed.ncbi.nlm.nih.gov/27414755
https://pubmed.ncbi.nlm.nih.gov/27414755
Publikováno v:
Journal of Pharmaceutical Sciences. 97:4446-4458
Even within an amorphous state, high energy sites can be generated due to sample handling and variations in preparation techniques can result in variation in these high energy sites. Such small handling variations may result in changes in physical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2896d375230f15f94b2f6c1c7891777
https://doi.org/10.1002/jps.21291
https://doi.org/10.1002/jps.21291
Publikováno v:
Journal of Pharmaceutical Sciences. 97:3830-3841
The aim of the present study is to determine if the correlation between molecular mobility and crystallization growth rates exists over a broad temperature range from temperatures below the glass transition ( T g ) to temperatures above the glass tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dea983a37403255455955f235988e3a
https://doi.org/10.1002/jps.21273
https://doi.org/10.1002/jps.21273
Publikováno v:
Pharmaceutical Research. 23:2277-2290
Predicting onsets of crystallization at temperatures below T (g), from data above T (g), would require that the correlation between crystallization onset and mobility is same above and below T (g), and the techniques being used to measure mobility ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d617cb2e40bde5d73e1e3f14f02eaf
https://doi.org/10.1007/s11095-006-9079-1
https://doi.org/10.1007/s11095-006-9079-1
Publikováno v:
Pharmaceutical Development and Technology. 10:33-40
The aim of this study is to investigate, by experimental studies and theoretical analysis, the phenomenon of cake shrinkage during the lyophilization process and to investigate the effect of shelf temperature during primary drying and secondary dryin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99528fff51de0814d330a30b78a91d9
https://doi.org/10.1081/pdt-35871
https://doi.org/10.1081/pdt-35871
Publikováno v:
Journal of pharmaceutical sciences. 103(12)
The nonisothermal crystallization kinetics of amorphous materials is routinely analyzed by statistically fitting the crystallization data to kinetic models. In this work, we systematically evaluate how the model-dependent crystallization kinetics is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb7911236b95a8400fc48fc48ad860c
https://pubmed.ncbi.nlm.nih.gov/25351553
https://pubmed.ncbi.nlm.nih.gov/25351553
Autor:
Chandan Bhugra, Zeren Wang, Changquan Calvin Sun, Li Zhong, Chitra Telang, Sayantan Chattoraj
Publikováno v:
Pharmaceutical research. 29(4)
To mechanistically explain the origin of two distinct non-isothermal crystallization modes, single-peak (unimodal) and two-peak (bimodal), of organic glasses.Glasses of ten organic molecules were prepared by melt-quenching and cryogenic milling of cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a79da389aca41dbd48ae5b38fd06f63
https://pubmed.ncbi.nlm.nih.gov/22173781
https://pubmed.ncbi.nlm.nih.gov/22173781
Publikováno v:
Journal of pharmaceutical sciences. 99(9)
The aim of this work is to determine if a stability testing protocol based on the correlations between crystallization onset and relaxation time above the glass transition temperature ( T g ) can be used to predict the crystallization onsets in amorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0292ec55dba52d95a84121936a7d3f1d
https://pubmed.ncbi.nlm.nih.gov/20575050
https://pubmed.ncbi.nlm.nih.gov/20575050