Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Chanchala D. Kaddi"'
Autor:
Ruth Abrams, Chanchala D. Kaddi, Mengdi Tao, Randolph J. Leiser, Giulia Simoni, Federico Reali, John Tolsma, Paul Jasper, Zachary vanRijn, Jing Li, Bradley Niesner, Jeffrey S. Barrett, Luca Marchetti, M. Judith Peterschmitt, Karim Azer, Susana Neves‐Zaph
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 7, Pp 374-383 (2020)
Gaucher’s disease type 1 (GD1) leads to significant morbidity and mortality through clinical manifestations, such as splenomegaly, hematological complications, and bone disease. Two types of therapies are currently approved for GD1: enzyme replacem
Externí odkaz:
https://doaj.org/article/2e477fd9552a478690827a03c69c9f70
Autor:
Karim Azer, Chanchala D. Kaddi, Jeffrey S. Barrett, Jane P. F. Bai, Sean T. McQuade, Nathaniel J. Merrill, Benedetto Piccoli, Susana Neves-Zaph, Luca Marchetti, Rosario Lombardo, Silvia Parolo, Selva Rupa Christinal Immanuel, Nitin S. Baliga
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Mathematical biology and pharmacology models have a long and rich history in the fields of medicine and physiology, impacting our understanding of disease mechanisms and the development of novel therapeutics. With an increased focus on the pharmacolo
Externí odkaz:
https://doaj.org/article/6043edfea4a0400f8fce0c682beb97f9
Autor:
Chanchala D. Kaddi, Bradley Niesner, Rena Baek, Paul Jasper, John Pappas, John Tolsma, Jing Li, Zachary van Rijn, Mengdi Tao, Catherine Ortemann‐Renon, Rachael Easton, Sharon Tan, Ana Cristina Puga, Edward H. Schuchman, Jeffrey S. Barrett, Karim Azer
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 442-452 (2018)
Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder with heterogeneous clinical manifestations, including hepatosplenomegaly and infiltrative pulmonary disease, and is associated with significant morbidity and mortality. Olip
Externí odkaz:
https://doaj.org/article/1e481f50dada49cf817e7e467ae2c956
Autor:
Danilo Tomasoni, Luca Marchetti, Giulia Simoni, Alessio Paris, Stefano Giampiccolo, Federico Reali, Corrado Priami, Chanchala D. Kaddi, Karim Azer, Rosario Lombardo, Susana Neves-Zaph
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Mathematical models have grown in size and complexity becoming often computationally intractable. In sensitivity analysis and optimization phases, critical for tuning, validation and qualification, these models may be run thousands of times. Scientif
Autor:
Enrico Domenici, Alan Ramponi, Danilo Tomasoni, Silvia Parolo, Susana Neves-Zaph, Karim Azer, Rosario Lombardo, Pranami Bora, Chanchala D. Kaddi
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Lysosomal storage diseases (LSDs) are characterized by the abnormal accumulation of substrates in tissues due to the deficiency of lysosomal proteins. Among the numerous clinical manifestations, chronic inflammation has been consistently reported for
Autor:
Susana Neves-Zaph, Rosario Lombardo, Jane P. F. Bai, Silvia Parolo, Karim Azer, Selva Rupa Christinal Immanuel, Luca Marchetti, Nathaniel J. Merrill, Nitin S. Baliga, Benedetto Piccoli, Jeffrey S. Barrett, Sean T. McQuade, Chanchala D. Kaddi
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
Mathematical biology and pharmacology models have a long and rich history in the fields of medicine and physiology, impacting our understanding of disease mechanisms and the development of novel therapeutics. With an increased focus on the pharmacolo
Autor:
Federico Reali, Corrado Priami, Luca Marchetti, Mengdi Tao, Giulia Simoni, Karim Azer, Chanchala D. Kaddi, Susana Neves-Zaph, Danilo Tomasoni
Publikováno v:
Bioinformatics (Oxford, England). 37(9)
Motivation Precision medicine is a promising field that proposes, in contrast to a one-size-fits-all approach, the tailoring of medical decisions, treatments or products. In this context, it is crucial to introduce innovative methods to stratify a po
Autor:
John E. Tolsma, Jing Li, Mengdi Tao, Ruth E. Abrams, Chanchala D. Kaddi, Karim Azer, Paul Jasper, Giulia Simoni, Randolph J Leiser, Jeffrey S. Barrett, Zachary van Rijn, Susana Neves-Zaph, M. Judith Peterschmitt, Federico Reali, Luca Marchetti, Bradley Niesner
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 7, Pp 374-383 (2020)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Gaucher's disease type 1 (GD1) leads to significant morbidity and mortality through clinical manifestations, such as splenomegaly, hematological complications, and bone disease. Two types of therapies are currently approved for GD1: enzyme replacemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e4a42df34cced36ad67b27d0b24f86
http://hdl.handle.net/11562/1021218
http://hdl.handle.net/11562/1021218
Autor:
Catherine Ortemann-Renon, Zachary van Rijn, Chanchala D. Kaddi, John E. Tolsma, Mengdi Tao, Edward H. Schuchman, Ana Cristina Puga, Rachael Easton, Bradley Niesner, John Pappas, Paul Jasper, Karim Azer, Jeffrey S. Barrett, Sharon Tan, Rena Baek, Jing Li
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 442-452 (2018)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder with heterogeneous clinical manifestations, including hepatosplenomegaly and infiltrative pulmonary disease, and is associated with significant morbidity and mortality. Olip
Autor:
Susana Zaph, Pablo Rendo, Danielle Holz, Isobelle Galeon, Chanchala D. Kaddi, David Reiner, Mengdi Tao
Publikováno v:
Blood. 138:1860-1860
Sickle cell disease (SCD) is caused by a mutation in the β-globin gene that produces abnormal hemoglobin (HbS), leading to clinical manifestations such as painful vaso-occlusive crises, anemia, and shortened lifespan due to organ damage. SAR445136 (