Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Autor: Baker, Lauren, Barnes, Caroline, Beveridge, Ryan, Cambridge, Emma, Carragher, Damian, Chana, Prabhjoat, Clarke, Kay, Hooks, Yvette, Igosheva, Natalia, Ismail, Ozama, Jackson, Hannah, Kane, Leanne, Lacey, Rosalind, Lafont, David Tino, Lucas, Mark, Maguire, Simon, McGill, Katherine, McIntyre, Rebecca E., Messager, Sophie, Mottram, Lynda, Mulderrig, Lee, Pearson, Selina, Protheroe, Hayley J., Roberson, Laura-Anne, Salsbury, Grace, Sanderson, Mark, Sanger, Daniel, Shannon, Carl, Thompson, Paul C., Tuck, Elizabeth, Vancollie, Valerie E., Brackenbury, Lisa, Bushell, Wendy, Cook, Ross, Dalvi, Priya, Gleeson, Diane, Habib, Bishoy, Hardy, Matt, Liakath-Ali, Kifayathullah, Miklejewska, Evelina, Price, Stacey, Sethi, Debarati, Trenchard, Elizabeth, von Schiller, Dominique, Vyas, Sapna, West, Anthony P., Woodward, John, Wynn, Elizabeth, Evans, Arthur, Gannon, David, Griffiths, Mark, Holroyd, Simon, Iyer, Vivek, Kipp, Christian, Lewis, Morag, Li, Wei, Oakley, Darren, Richardson, David, Smedley, Damian, Agu, Chukwuma, Bryant, Jackie, Delaney, Liz, Gueorguieva, Nadia I., Tharagonnet, Helen, Townsend, Anne J., Biggs, Daniel, Brown, Ellen, Collinson, Adam, Dumeau, Charles-Etienne, Grau, Evelyn, Harrison, Sarah, Harrison, James, Ingle, Catherine E., Kundi, Helen, Madich, Alla, Mayhew, Danielle, Metcalf, Tom, Newman, Stuart, Pass, Johanna, Pearson, Laila, Reynolds, Helen, Sinclair, Caroline, Wardle-Jones, Hannah, Woods, Michael, Alexander, Liam, Brown, Terry, Flack, Francesca, Frost, Carole, Griggs, Nicola, Hrnciarova, Silvia, Kirton, Andrea, McDermott, Jordan, Rogerson, Claire, White, Gemma, Zielezinski, Pawel, DiTommaso, Tia, Edwards, Andrew, Heath, Emma, Mahajan, Mary Ann, Yalcin, Binnaz, White, Jacqueline K., Gerdin, Anna-Karin, Karp, Natasha A., Ryder, Ed, Buljan, Marija, Bussell, James N., Salisbury, Jennifer, Clare, Simon, Ingham, Neil J., Podrini, Christine, Houghton, Richard, Estabel, Jeanne, Bottomley, Joanna R., Melvin, David G., Sunter, David, Adams, Niels C., Tannahill, David, Logan, Darren W., MacArthur, Daniel G., Flint, Jonathan, Mahajan, Vinit B., Tsang, Stephen H., Smyth, Ian, Watt, Fiona M., Skarnes, William C., Dougan, Gordon, Adams, David J., Ramirez-Solis, Ramiro, Bradley, Allan, Steel, Karen P.

Publikováno v: In Cell 18 July 2013 154(2):452-464

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CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner

Autor: Canavan, James B., Tree, Timothy, Dowson, Sophie E., Khamri, Wafa, Kordasti, Shahram Y., Mitchell, Peter J., Grimbacher, Bodo, Edozie, Francis C., Taams, Leonie S., Afzali, Behdad, Walter, Gina, Lechler, Robert I., Scotta, Cristiano, Heck, Susanne, John, Susan, Povoleri, Giovanni A. M., Cope, Andrew P., Menon, Bina, Lombardi, Giovanna, Demandt, Laura, Chana, Prabhjoat S.

Publikováno v: European Journal of Immunology
Afzali, B, Mitchell, P J, Edozie, F C, Povoleri, G A M, Dowson, S E, Demandt, L, Walter, G, Canavan, J B, Scotta, C, Menon, B, Chana, P S, Khamri, W, Kordasti, S, Heck, S, Grimbacher, B, Tree, T, Cope, A P, Taams, L S, Lechler, R I, John, S & Lombardi, G 2013, ' CD161 expression characterizes a sub-population of human regulatory T cells that produces IL-17 in a STAT3 dependent manner ', European Journal of Immunology, vol. 43, no. 8, pp. 2043-2054 . https://doi.org/10.1002/eji.201243296

Treg cells are critical for the prevention of autoimmune diseases and are thus prime candidates for cell-based clinical therapy. However, human Treg cells are "plastic", and are able to produce IL-17 under inflammatory conditions. Here, we identify a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9b69b28ad84efa864d2d07cd1cd099
https://pubmed.ncbi.nlm.nih.gov/23677517

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