Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Chan-I Chung"'
Autor:
Wen-Hao Guo, Xiaoli Qi, Xin Yu, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Dong Lu, Lingfei Wang, Jianwei Chen, Lynn Hsiao Su, Krystle J. Nomie, Feng Li, Meng C. Wang, Xiaokun Shu, José N. Onuchic, Jennifer A. Woyach, Michael L. Wang, Jin Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
PROTACs have emerged as promising therapeutic agents but their cellular uptake is often inefficient. Here, the authors show that reversible covalent warhead chemistry improves PROTAC intracellular accumulation and target engagement, and develop a dua
Externí odkaz:
https://doaj.org/article/4979b2c9fe654e15a019e2b5da2998c8
Autor:
Chan-I. Chung, Junjiao Yang, Xiaoyu Yang, Hongjiang Liu, Zhimin Ma, Szulzewsky, Frank, Holland, Eric C., Yin Shen, Xiaokun Shu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/13/2024, Vol. 121 Issue 7, p1-12, 29p
Autor:
Junjiao Yang, Yinghong Xiao, Peter V. Lidsky, Chien-Ting Wu, Luke R. Bonser, Shiming Peng, Miguel A. Garcia-Knight, Michel Tassetto, Chan-I Chung, Xiaoquan Li, Tsuguhisa Nakayama, Ivan T. Lee, Jayakar V. Nayak, Khadija Ghias, Kirsten L. Hargett, Brian K. Shoichet, David J. Erle, Peter K. Jackson, Raul Andino, Xiaokun Shu
Publikováno v:
Nat Microbiol
Nature microbiology, vol 8, iss 1
Nature microbiology, vol 8, iss 1
The coronavirus SARS-CoV-2 causes the severe disease COVID-19. SARS-CoV-2 infection is initiated by interaction of the viral spike protein and host receptor angiotensin-converting enzyme 2 (ACE2). We report an improved bright and reversible fluorogen
Publikováno v:
Science Advances. 9
The kinase ataxia telangiectasia mutated (ATM) plays a key role in the DNA damage response (DDR). It is thus essential to visualize spatiotemporal dynamics of ATM activity during DDR. Here, we designed a robust ATM activity reporter based on phosphor
Autor:
Junjiao Yang, Chan-I Chung, Jessica Koach, Hongjiang Liu, Qian Zhao, Xiaoyu Yang, Yin Shen, William A. Weiss, Xiaokun Shu
Dysregulation and enhanced expression of MYC transcription factors including MYC and MYCN contribute to majority of human cancers. For example, MYCN is amplified up to several hundred-fold in high-risk neuroblastoma. One potential consequence of elev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c36341cef107b37e249fcdfd02cd836
https://doi.org/10.1101/2022.06.28.498043
https://doi.org/10.1101/2022.06.28.498043
Autor:
Chan I. Chung
Publikováno v:
Extrusion of Polymers. :I-XXIV
Autor:
Chan I. Chung
Publikováno v:
Extrusion of Polymers. :475-485
Autor:
Fang Bai, Xin Yu, José N. Onuchic, Krystle Nomie, Jianwei Chen, Lynn Hsiao Su, Michael L. Wang, Chan-I Chung, Jennifer A. Woyach, Lingfei Wang, Meng C. Wang, Jin Wang, Wen-Hao Guo, Dong Lu, Yang Liu, Feng Li, Xingcheng Lin, Xiaoli Qi, Xiaokun Shu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing an appropriate E3 ligase for the target protein, improving the binding affinities towards the target protein and the E3 ligase, and optimizing the PROTAC lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642e6c250fae36146fc21fd0f9c8432e