Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chan Wang Jerry Lio"'
Autor:
Heng-Yi Chen, Ana Almonte-Loya, Fang-Yun Lay, Michael Hsu, Eric Johnson, Edahí González-Avalos, Jieyun Yin, Richard S Bruno, Qin Ma, Hazem E Ghoneim, Daniel J Wozniak, Fiona E Harrison, Chan-Wang Jerry Lio
Publikováno v:
eLife, Vol 11 (2022)
Ascorbate (vitamin C) is an essential micronutrient in humans. The severe chronic deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular an
Externí odkaz:
https://doaj.org/article/c4239ce054af46e581239b891b09faf5
Autor:
Atsushi Onodera, Edahí González-Avalos, Chan-Wang Jerry Lio, Romain O. Georges, Alfonso Bellacosa, Toshinori Nakayama, Anjana Rao
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not reco
Externí odkaz:
https://doaj.org/article/22b84e20f85e4b3baaf5156ae16cde0f
Autor:
Rafael Bejar, Anjana Rao, Yun Huang, Kun Zhang, Dinh Diep, Tiffany Tanaka, Laura Williamson, Minjung Lee, Emily C. Wheeler, Edahí González-Avalos, Chan-Wang Jerry Lio, Soo Park, Timothy Luger, Brian M. Reilly
DNA methyltransferase inhibitors (DNMTI) like 5-Azacytidine (5-Aza) are the only disease-modifying drugs approved for the treatment of higher-risk myelodysplastic syndromes (MDS), however less than 50% of patients respond, and there are no predictors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15751a727a4cd1f9bf11ada4fc5cc766
https://doi.org/10.1158/1541-7786.c.6544947.v1
https://doi.org/10.1158/1541-7786.c.6544947.v1
Autor:
Rafael Bejar, Anjana Rao, Yun Huang, Kun Zhang, Dinh Diep, Tiffany Tanaka, Laura Williamson, Minjung Lee, Emily C. Wheeler, Edahí González-Avalos, Chan-Wang Jerry Lio, Soo Park, Timothy Luger, Brian M. Reilly
A) Expression of hemoglobin genes which increase in terminally differentiated erythroid cells. B) Expression of key erythrocyte marker genes. TPM=Transcripts per kilobase million; a gene expression measure for RNAseq that normalizes for gene-length a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623466af5b0b36d4e69432ea7848fc64
https://doi.org/10.1158/1541-7786.22525878
https://doi.org/10.1158/1541-7786.22525878
Autor:
Rafael Bejar, Anjana Rao, Yun Huang, Kun Zhang, Dinh Diep, Tiffany Tanaka, Laura Williamson, Minjung Lee, Emily C. Wheeler, Edahí González-Avalos, Chan-Wang Jerry Lio, Soo Park, Timothy Luger, Brian M. Reilly
A) Dose-response curve of wild-type TF1 cell viability for three different lengths of 5-Aza treatments (1 dose per day for a total length of treatment between 1 and 3 days). Points represent replicates per condition, shaded region corresponds to 95%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00da746ccd74bf3f24f9df60068c0885
https://doi.org/10.1158/1541-7786.22525887.v1
https://doi.org/10.1158/1541-7786.22525887.v1
Autor:
Rafael Bejar, Anjana Rao, Yun Huang, Kun Zhang, Dinh Diep, Tiffany Tanaka, Laura Williamson, Minjung Lee, Emily C. Wheeler, Edahí González-Avalos, Chan-Wang Jerry Lio, Soo Park, Timothy Luger, Brian M. Reilly
Cells were treated with 100uM L-AA or vehicle 24hrs before DNA isolation. A) 5hmC dot blot for L-AA treated or untreated Cells. B) Standard curve of 5hmC densitometric signal vs. pmol (calculated from 5hmC standard with known 5hmC amount). C) Quantif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11adce67c9c056e6c144befbed6938cb
https://doi.org/10.1158/1541-7786.22525890.v1
https://doi.org/10.1158/1541-7786.22525890.v1
Autor:
Rafael Bejar, Anjana Rao, Yun Huang, Kun Zhang, Dinh Diep, Tiffany Tanaka, Laura Williamson, Minjung Lee, Emily C. Wheeler, Edahí González-Avalos, Chan-Wang Jerry Lio, Soo Park, Timothy Luger, Brian M. Reilly
Line plots in grid: each colored line represents a single CpG locus over time after 5-Aza treatment. Black line indicates mean value for that cluster group. Dotted black line indicates mean +/- 1 standard deviation. From left to right: clustering sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbb7b132329df7d98bca39726bf1946
https://doi.org/10.1158/1541-7786.22525881
https://doi.org/10.1158/1541-7786.22525881
Publikováno v:
Annu Rev Immunol
Cell identity and function largely rely on the programming of transcriptomes during development and differentiation. Signature gene expression programs are orchestrated by regulatory circuits consisting of cis-acting promoters and enhancers, which re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b1a04d7a292ef0a0e3795adbfd2abd
https://doi.org/10.1146/annurev-immunol-101320-025949
https://doi.org/10.1146/annurev-immunol-101320-025949
Autor:
Lydia N. Raines, Haoxin Zhao, Yuzhu Wang, Heng-Yi Chen, Hector Gallart-Ayala, Pei-Chun Hsueh, Wei Cao, Yeojung Koh, Ana Alamonte-Loya, Pu-Ste Liu, Julijana Ivanisevic, Chan-Wang Jerry Lio, Ping-Chih Ho, Stanley Ching-Cheng Huang
Publikováno v:
Nat Immunol
Chronic inflammation triggers compensatory immunosuppression to stop inflammation and minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress augments the suppressive phenotypes of immune cells; however, the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bc9a34c387eb3f332dce0362a8fb19
https://doi.org/10.1038/s41590-022-01145-x
https://doi.org/10.1038/s41590-022-01145-x
Publikováno v:
Immunol Rev
Micronutrients are essential small molecules required by organisms in minute quantity for survival. For instance, vitamins and minerals, the two major categories of micronutrients, are central for biological processes such as metabolism, cell replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f02947b6192ff6a72cf0c0fa47c5a7
https://doi.org/10.1111/imr.13045
https://doi.org/10.1111/imr.13045