Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chan Lek Tan"'
Autor:
Jamie S. Ahn, Erica L. Huey, Timothy V. Corpuz, Christopher A. Zimmerman, Linda Madisen, Yiming Chen, Lisa R. Beutler, Ling Bai, Hongkui Zeng, Seher Kosar, Chan Lek Tan, Zachary A. Knight
Publikováno v:
Nature
Nature, vol 568, iss 7750
Nature, vol 568, iss 7750
Satiation is the process by which eating and drinking reduce appetite. For thirst, oropharyngeal cues have a critical role in driving satiation by reporting to the brain the volume of fluid that has been ingested1-12. By contrast, the mechanisms that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d311308fa0537fe50e4163ace0e9f29
http://europepmc.org/articles/PMC6483081
http://europepmc.org/articles/PMC6483081
Autor:
Zachary A. Knight, Chan Lek Tan
Publikováno v:
Neuron, vol 98, iss 1
The regulation of body temperature is one of the most critical functions of the nervous system. Here we review our current understanding of thermoregulation in mammals. We outline the molecules and cells that measure body temperature in the periphery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ca7ce96a3007a8d5b1e15b3c706203
https://doi.org/10.1016/j.neuron.2018.02.022
https://doi.org/10.1016/j.neuron.2018.02.022
Autor:
Chan Lek Tan1,2, Plotkin, Joshua L.3, Venø, Morten T.4, von Schimmelmann, Melanie1,5, Feinberg, Philip1,5, Mann, Silas1,5, Handler, Annie1, Kjems, Jørgen4, Surmeier, D. James3, O'Carroll, Dónal6,7, Greengard, Paul1, Schaefer, Anne1,5 anne.schaefer@mssm.edu
Publikováno v:
Science. 12/6/2013, Vol. 342 Issue 6163, preceding p1254-1258. 6p.
Autor:
Franz Weber, Wei-Cheng Chang, Johnny Phong Hoang Do, Hongkui Zeng, Shinjae Chung, Thuc Nghi Nguyen, Nikolai Hörmann, Chan Lek Tan, Kevin T. Beier, Liqun Luo, Peng Zhong, Michael J. Krashes, Shenqin Yao, Bosiljka Tasic, Yang Dan, Zhe Zhang, Ali Cetin, Zachary A. Knight
Publikováno v:
Nature
Identification of sleep-active and sleep-promoting neurons in the preoptic area of the hypothalamus using neural projection tracing tools to target this population among a group of intermingled neurons, all with various functions. The preoptic area (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe240ab1881e861eb1c6314e3e986f
https://pubmed.ncbi.nlm.nih.gov/28514446
https://pubmed.ncbi.nlm.nih.gov/28514446
Autor:
Zachary A. Knight, Yen-Chu Lin, Chan Lek Tan, David E. Leib, Christopher A. Zimmerman, Gwendolyn E. Daly, Elizabeth K. Cooke
Publikováno v:
Cell, vol 167, iss 1
Thermoregulation is one of the most vital functions of the brain, but how temperature information is converted into homeostatic responses remains unknown. Here, we use an unbiased approach for activity-dependent RNA sequencing to identify warm-sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c0c5fdcbb73927deaace5c60a7fd57
https://escholarship.org/uc/item/6qn3j4s1
https://escholarship.org/uc/item/6qn3j4s1
Autor:
Anne Schaefer, Chan Lek Tan, Mutsuyuki Sugimori, Dónal O'Carroll, Dean E. Hillman, Rodolfo R. Llinás, Paul Greengard
Publikováno v:
The Journal of Experimental Medicine
Genome-encoded microRNAs (miRNAs) are potent regulators of gene expression. The significance of miRNAs in various biological processes has been suggested by studies showing an important role of these small RNAs in regulation of cell differentiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658c11badd9d04dead93723cbadd302b
https://doi.org/10.1084/jem.20070823
https://doi.org/10.1084/jem.20070823
Autor:
Ailar Poormoghaddam, Yiming Chen, Erica L. Huey, Jamie S. Ahn, Yen-Chu Lin, David E. Leib, Chan Lek Tan, Zachary A. Knight, Christopher A. Zimmerman
Publikováno v:
Neuron, vol 96, iss 6
The brain transforms the need for water into the desire to drink, but how this transformation is performed remains unknown. Here we describe the motivational mechanism by which the forebrain thirst circuit drives drinking. We show that thirst-promoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8d1928902a5de17fd0f5ffe77c61b3
https://doi.org/10.1016/j.neuron.2017.11.041
https://doi.org/10.1016/j.neuron.2017.11.041
Autor:
Melanie von Schimmelmann, Paul Greengard, Chan Lek Tan, Dónal O'Carroll, D. James Surmeier, Anne Schaefer, Philip A Feinberg, Morten T. Venø, Joshua L. Plotkin, Silas Mann, Annie Handler, Jørgen Kjems
Publikováno v:
Science
Tan, C L, Plotkin, J L, Venø, M T, von Schimmelmann, M, Feinberg, P, Mann, S, Handler, A, Kjems, J, Surmeier, D J, O’Carroll, D, Greengard, P & Schaefer, A 2013, ' MicroRNA-128 governs neuronal excitability and motor behavior in mice ', Science, vol. 342, no. 6163, pp. 1254-1258 . https://doi.org/10.1126/science.1244193
Tan, C L, Plotkin, J L, Venø, M T, von Schimmelmann, M, Feinberg, P, Mann, S, Handler, A, Kjems, J, Surmeier, D J, O’Carroll, D, Greengard, P & Schaefer, A 2013, ' MicroRNA-128 governs neuronal excitability and motor behavior in mice ', Science, vol. 342, no. 6163, pp. 1254-1258 . https://doi.org/10.1126/science.1244193
Not Too Much, Not Too Little The microRNA miR128 is expressed in brain neurons of the mouse. Lek Tan et al. (p. 1254 ) now find that miR128 is crucial to stable brain function. Mice deficient in miR128 developed hyperactivity and were susceptible to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e94b6853b1d638b0d63448a336ac449
https://hdl.handle.net/21.11116/0000-000B-6E70-C
https://hdl.handle.net/21.11116/0000-000B-6E70-C