Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chan Kou Hwang"'
Autor:
Alex Romero, Youe-Kong Shue, Ken Marby, Jonathan Duffield, Po Yee Leung, Chang-Hsing Liang, Steven J. Sucheck, Yoshitaka Ichikawa, Chan-Kou Hwang, Yu-Hung Chiu, Sulan Yao, David Rabuka
Publikováno v:
Tetrahedron Letters. 46:1483-1487
A new and efficient route to a ketolide aglycon served as a basis for the unprecedented 5-O-glyco-modification of ketolide antibiotics. Combined with an effective copper-catalyzed triazole-forming reaction a series of novel and potent ketolide antibi
Autor:
Yoshitaka Ichikawa, David Rabuka, San-Bao Hwang, Sulan Yao, Mayling L. Cheng, Sean M. O'Hare, Chan-Kou Hwang, Pamela Sears, Kenneth Marby, Steven J. Sucheck, Paulo W.M. Sgarbi, Changyong Hu, Mrunali Bairi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3733-3738
Glyco-optimization (OPopS TM ) of aminoglycosides has been performed by replacing the existing sugar moiety with a variety of sugar derivatives. Glycosylation of the 6-position of nebramine provided a library of novel 4,6-linked aminoglycosides (AMGs
Autor:
Shuhao Shi, Peter Gärtner, C. V. C. Prasad, Paul A. Wallace, William W. Ogilvie, Konstantinos A. Agrios, John Hutchinson, Chan-Kou Hwang, Guo-qiang Shi, Mark E. Bunnage, Chris A. Veale, Zhen Yang, Kyriacos C. Nicolaou, Janet L. Gunzner, Michael A. Ouellette
Publikováno v:
Chemistry - A European Journal. 5:628-645
Pivotal intermediates in the total synthesis of brevetoxin A are the BCDE and the GHIJ ring systems. Several of the previously developed methodologies such as hydroxy epoxide cyclizations, hydroxy dithioketal cyclizations, and Pd-catalyzed coupling w
Autor:
Beth-Ann Badea, Chan Kou Hwang, Youssef L. Bennani, Laura J. Dar-ti, Stacie S. Canan Koch, Kristin S. Marron, Alex M. Nadzan
Publikováno v:
Tetrahedron Letters. 37:8109-8112
The treatment of bicyclic and tricyclic ketones with lithium ethynyl acetylide, followed by the addition of a catalytic amount of CSA or p-TSA, affords the corresponding exocyclic olefinic ester in good yields, and geometric ratios up to 13:1 favorin
Autor:
A. M. Nadzan, Dardashti Laura J, Beth Ann Badea, S. S. Canan Koch, Chan Kou Hwang, Kristin S. Marron, Youssef L. Bennani
Publikováno v:
ChemInform. 28
Autor:
Chang-Hsing Liang, Po Yee Leung, Alex Romero, Sulan Yao, Chan-Kou Hwang, Pamela Sears, Yu-Hung Chiu, Yoshitaka Ichikawa, Jaime Seddon, Nicole Robert
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(5)
A series of new triazole-containing ketolides and 2-fluoro-ketolides in which the 5-O-desosamine was replaced by unnatural sugars were synthesized and evaluated against relevant macrolide-sensitive and macrolide-resistant respiratory pathogens. Excel