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R-loops exert varied beneficial or detrimental effects. To assess the function of an R-loop at a specific genetic locus, we had developed an inducible RNaseH1-EGFP-dCas9 (RED) protein chimaera as part of a locus-associated R-loop-modulating system (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::004a96d083865a4f769b78f86a75a015
https://doi.org/10.1101/2021.05.25.445644
https://doi.org/10.1101/2021.05.25.445644
Autor:
Shokrollahi M; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Stanic M; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Hundal A; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Research Centre, University Health Network, Toronto, Ontario, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Urman D; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Jordan CA; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Hakem A; Princess Margaret Cancer Research Centre, University Health Network, Toronto, Ontario, Canada., Espin R; ProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.; Biomedical Research Network Centre in Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Hao J; Princess Margaret Cancer Research Centre, University Health Network, Toronto, Ontario, Canada., Krishnan R; Princess Margaret Cancer Research Centre, University Health Network, Toronto, Ontario, Canada., Maass PG; Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Dickson BC; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Hande MP; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Pujana MA; ProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.; Biomedical Research Network Centre in Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Hakem R; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. razq.hakem@uhnresearch.ca.; Princess Margaret Cancer Research Centre, University Health Network, Toronto, Ontario, Canada. razq.hakem@uhnresearch.ca.; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. razq.hakem@uhnresearch.ca., Mekhail K; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. karim.mekhail@utoronto.ca.; Temerty Centre for AI Research and Education in Medicine, University of Toronto, Toronto, Ontario, Canada. karim.mekhail@utoronto.ca.; College of New Scholars, Artists and Scientists, Royal Society of Canada, Ottawa, Ontario, Canada. karim.mekhail@utoronto.ca.
Publikováno v:
Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Sep; Vol. 31 (9), pp. 1319-1330. Date of Electronic Publication: 2024 Apr 17.
Autor:
Yerlici VT; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada., Astori A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Kejiou NS; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada., Jordan CA; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada., Khosraviani N; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada., Hakem R; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada., Palazzo AF; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada., Mekhail K; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada. Electronic address: karim.mekhail@utoronto.ca.
Publikováno v:
Cell reports [Cell Rep] 2024 Mar 26; Vol. 43 (3), pp. 113891. Date of Electronic Publication: 2024 Feb 29.
Autor:
Khosraviani N; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ON, Canada., Abraham KJ; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ON, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ON, Canada. Electronic address: janetny.chan@utoronto.ca., Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ON, Canada; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, Canada. Electronic address: karim.mekhail@utoronto.ca.
Publikováno v:
STAR protocols [STAR Protoc] 2022 Dec 16; Vol. 3 (4), pp. 101734. Date of Electronic Publication: 2022 Sep 29.
Autor:
Todd LA; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, M5G 1M1, Canada., Hall AC; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, M5G 1M1, Canada., Pietrobon V; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, M5G 1M1, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, M5G 1M1, Canada., Laflamme G; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, M5G 1M1, Canada., Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, M5G 1M1, Canada. karim.mekhail@utoronto.ca.; Faculty of Medicine, Canada Research Chairs Program, University of Toronto, Toronto, ON, M5G 1M1, Canada. karim.mekhail@utoronto.ca.
Publikováno v:
Scientific reports [Sci Rep] 2020 Sep 29; Vol. 10 (1), pp. 16034. Date of Electronic Publication: 2020 Sep 29.
Autor:
Abraham KJ; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Khosraviani N; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Gorthi A; Greehey Children's Cancer Research Institute, Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA., Samman A; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Zhao DY; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada., Wang M; Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA., Bokros M; Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA., Vidya E; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Ostrowski LA; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Oshidari R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Pietrobon V; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Patel PS; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Algouneh A; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Singhania R; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Liu Y; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Yerlici VT; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., De Carvalho DD; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Ohh M; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Dickson BC; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Hakem R; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Greenblatt JF; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada., Lee S; Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA., Bishop AJR; Greehey Children's Cancer Research Institute, Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health at San Antonio, San Antonio, TX, USA., Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. karim.mekhail@utoronto.ca.; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. karim.mekhail@utoronto.ca.
Publikováno v:
Nature [Nature] 2020 Sep; Vol. 585 (7824), pp. 298-302. Date of Electronic Publication: 2020 Jul 15.
Autor:
Ostrowski LA; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Hall AC; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Szafranski KJ; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Oshidari R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Abraham KJ; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Krustev C; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Zhang K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Wang A; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Liu Y; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Guo R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada. karim.mekhail@utoronto.ca.; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada. karim.mekhail@utoronto.ca.
Publikováno v:
Communications biology [Commun Biol] 2018 Nov 05; Vol. 1, pp. 187. Date of Electronic Publication: 2018 Nov 05 (Print Publication: 2018).
Autor:
Oshidari R; Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto, West Tower, 661 University Avenue, Toronto, ON, M5G 1M1, Canada., Strecker J; Department of Molecular Genetics, MaRS Centre, University of Toronto, West Tower, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.; Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA, 02142, USA., Chung DKC; Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto, West Tower, 661 University Avenue, Toronto, ON, M5G 1M1, Canada., Abraham KJ; Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto, West Tower, 661 University Avenue, Toronto, ON, M5G 1M1, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto, West Tower, 661 University Avenue, Toronto, ON, M5G 1M1, Canada., Damaren CJ; Institute for Aerospace Studies, University of Toronto, 4925 Dufferin Street, Toronto, ON, M3H 5T6, Canada., Mekhail K; Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto, West Tower, 661 University Avenue, Toronto, ON, M5G 1M1, Canada. karim.mekhail@utoronto.ca.; Canada Research Chairs Program, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. karim.mekhail@utoronto.ca.
Publikováno v:
Nature communications [Nat Commun] 2018 Jul 02; Vol. 9 (1), pp. 2567. Date of Electronic Publication: 2018 Jul 02.