Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Chan Choo Yap"'
Autor:
Chan Choo Yap, Bettina Winckler
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 570-575 (2022)
Dendrites differ from axons in multiple ways, including the presence of minus-end out microtubules intermixed with the more conventional plus-end out microtubules. The mixed microtubule polarity makes regulation of directional transport in dendrites
Externí odkaz:
https://doaj.org/article/c77bd08538bf415c8076dc6719bc849a
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140010 (2015)
The brain consists of many distinct neuronal cell types, but which cell types are present in widely used primary cultures of embryonic rodent brain is often not known. We characterized how abundantly four cell type markers (Ctip2, Satb2, Prox1, GAD65
Externí odkaz:
https://doaj.org/article/10fdb06696a8474d80f955e1d9d34196
Autor:
Mulligan, Ryan J., Magaj, Magdalena M., Digilio, Laura, Redemann, Stefanie, Chan Choo Yap, Winckler, Bettina
Publikováno v:
Journal of Cell Science; May2024, Vol. 137 Issue 9, p1-21, 21p
Publikováno v:
bioRxiv
In neurons, degradation of dendritic cargos requires RAB7 and dynein-mediated retrograde transport to somatic lysosomes. In order to test if the dynein adaptor RILP (RAB-interacting lysosomal protein) mediated the recruitment of dynein to late endoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fce1f7882969a2610ae6f2ba6a6ec6
https://europepmc.org/articles/PMC10028860/
https://europepmc.org/articles/PMC10028860/
Publikováno v:
J Neurosci
In all cell types, endocytosed cargo is transported along a set of endosomal compartments, which are linked maturationally from early endosomes (EEs) via late endosomes (LEs) to lysosomes. Lysosomes are critical for degradation of proteins that enter
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d6e0aa40540409f47f6147df9d50fd
https://doi.org/10.1007/978-1-0716-2639-9_36
https://doi.org/10.1007/978-1-0716-2639-9_36
RILP is one of many effectors of RAB7 which bind to RAB7 in its activated GTP-bound state. The exact mechanism by which RAB7 effectors interact with RAB7 in time and space is not well understood. One of the known functions of RILP is to recruit dynei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ee14f4ea555a5162637beb4a734f46
https://doi.org/10.1101/2022.11.01.514750
https://doi.org/10.1101/2022.11.01.514750
Publikováno v:
Curr Opin Neurobiol
All cells are filled with membrane-bound organelles which are responsible for the synthesis and transport as well as degradation of membrane proteins. The localization of these organelles inside cells is highly regulated. The regulation of organelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e1e9f3308f959cdd18903f4b3a584f
https://europepmc.org/articles/PMC9167696/
https://europepmc.org/articles/PMC9167696/
Kymograph analysis is commonly used by researchers to study dynamic processes in cells. Current tools widely available only allow for analysis of one channel kymographs. Here we provide a python-coded, open source program to use as a plug-in for Imag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6047ce4bbe4fdc27cbeb7e9472d5f199
https://doi.org/10.1101/2021.11.29.470387
https://doi.org/10.1101/2021.11.29.470387
Autor:
Chan Choo Yap, Bettina Winckler
Publikováno v:
Developmental biology. 486
Many membrane proteins are highly enriched in either dendrites or axons. This non-uniform distribution is a critical feature of neuronal polarity and underlies neuronal function. The molecular mechanisms responsible for polarized distribution of memb