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Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

Autor: García, H.D., Bei, Y., von Stebut, J., Ibáñez, G., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Pusch, F.F., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Schulte, J.H., Haase, K., Scheer, M., Ortiz, M.V., Henssen, A.G.

Pathognomonic PAX3-FOXO1 fusion oncogene expression is associated with poor outcome in rhabdomyosarcoma. Combining genome-wide CRISPR screening with cell-based functional genetic approaches, we here provide evidence that PAX3-FOXO1 induces replicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::bb5a940f992b1dd21f52c112b0042f4b
http://edoc.mdc-berlin.de/19709/1/19709oa.pdf

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Coordinated inheritance of extrachromosomal DNAs in cancer cells.

Autor: Hung KL; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Jones MG; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Wong IT; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA., Curtis EJ; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA.; School of Medicine, University of California at San Diego, La Jolla, CA, USA., Lange JT; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA., He BJ; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Luebeck J; Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA., Schmargon R; Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Scanu E; Department of Mathematics, Queen Mary University of London, London, UK., Brückner L; Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max-Delbrück-Centrum für Molekulare Medizin (BIMSB/BIH), Berlin, Germany., Yan X; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Li R; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Gnanasekar A; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA., Chamorro González R; Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Belk JA; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Liu Z; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Melillo B; Department of Chemistry, Scripps Research, La Jolla, CA, USA.; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Bafna V; Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA., Dörr JR; Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Werner B; Evolutionary Dynamics Group, Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Huang W; Department of Mathematics, Queen Mary University of London, London, UK.; Group of Theoretical Biology, The State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou, China., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA, USA.; Vividion Therapeutics, San Diego, CA, USA., Henssen AG; Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin and German Cancer Research Center DKFZ, Heidelberg, Germany.; Berlin Institute of Health, Berlin, Germany., Mischel PS; Sarafan ChEM-H, Stanford University, Stanford, CA, USA. pmischel@stanford.edu.; Department of Pathology, Stanford University, Stanford, CA, USA. pmischel@stanford.edu., Chang HY; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. howchang@stanford.edu.; Department of Genetics, Stanford University, Stanford, CA, USA. howchang@stanford.edu.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8037), pp. 201-209. Date of Electronic Publication: 2024 Nov 06.