Výsledky vyhledávání - "Chamodi K. Gardhi"

Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

Autor: Chamodi K. Gardhi, Tatiana P. Soares da Costa, Matthew A. Perugini, Belinda M. Abbott, Rebecca M. Christoff

Publikováno v: MedChemComm. 10:1581-1588

Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The development of inhibitors of the enzyme dihydrodipicolinate synthase (DHDPS), which is involved in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90f4f11912ab0456b429c5ad3f4b2f74
https://doi.org/10.1039/c9md00107g

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Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation

Autor: Leslie W. Deady, Nathan J. O'Brien, Elliott D. Cope, Brendan S. Crabb, Belinda M. Abbott, Chamodi K. Gardhi, Greta E. Weiss, Melissa J. Buskes, Rebecca M. Christoff, Robabeh Kalhor, Paul R. Gilson, Boris Prinz, Dene R. Littler, Benjamin J. Richards, Katherine L. Harvey

Publikováno v: Organic & Biomolecular Chemistry. 14:4617-4639

Central to malaria pathogenesis is the invasion of human red blood cells by Plasmodium falciparum parasites. Following each cycle of intracellular development and replication, parasites activate a cellular program to egress from their current host ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc507a46e38bcf23e43e61926e9a482e
https://doi.org/10.1039/c5ob02517f

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Quaternary Structure Analyses of an Essential Oligomeric Enzyme

Autor: Tatiana P, Soares da Costa, Janni B, Christensen, Sebastien, Desbois, Shane E, Gordon, Ruchi, Gupta, Campbell J, Hogan, Tao G, Nelson, Matthew T, Downton, Chamodi K, Gardhi, Belinda M, Abbott, John, Wagner, Santosh, Panjikar, Matthew A, Perugini

Publikováno v: Methods in enzymology. 562

Here, we review recent studies aimed at defining the importance of quaternary structure to a model oligomeric enzyme, dihydrodipicolinate synthase. This will illustrate the complementary and synergistic outcomes of coupling the techniques of analytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a945e16d49622716dace2b7e71aea59
https://pubmed.ncbi.nlm.nih.gov/26412653

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