HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy

Autor: Kelly, C, Mwandumba, HC, Heyderman, RS, Jambo, K, Kamng'ona, R, Chammudzi, M, Sheha, I, Peterseon, I, Rapala, A, Mallewa, J, Walker, AS, Klein, N, Khoo, S

Background The contribution of immune activation to arterial stiffness and its reversibility in HIV-infected adults in sub-Saharan Africa is unknown. Methods HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with

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https://doi.org/10.1093/infdis/jiz015

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Circulating microparticles are increased amongst people presenting with HIV and advanced immune suppression in Malawi and correlate closely with arterial stiffness: a nested case control study.

Autor: Kelly C; Centre for Experimental Pathogen Host Research, UCD, Dublin, Ireland.; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi, Malawi.; Institute of Translational Medicine, University of Liverpool, Liverpool, UK., Gurung R; Institute of Infection, immunity and Inflammation, UCL, London, UK., Kamng'ona R; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi, Malawi., Sheha I; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi, Malawi., Chammudzi M; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi, Malawi., Jambo K; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi, Malawi.; Liverpool School of Tropical Medicine, LSTM, Liverpool, UK., Mallewa J; College of Medicine, University of Malawi, Blantyre, Malawi., Rapala A; Institute of Cardiovascular Science, UCL, London, UK., Heyderman R; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi, Malawi.; Institute of Infection, immunity and Inflammation, UCL, London, UK., Mallon P; Centre for Experimental Pathogen Host Research, UCD, Dublin, Ireland., Mwandumba H; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi, Malawi.; Liverpool School of Tropical Medicine, LSTM, Liverpool, UK., Khoo S; Institute of Translational Medicine, University of Liverpool, Liverpool, UK., Klein N; Institute of Infection, immunity and Inflammation, UCL, London, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2021 Oct 13; Vol. 6, pp. 264. Date of Electronic Publication: 2021 Oct 13 (Print Publication: 2021).