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The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer

Publikováno v: Cancers
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Trastuzumab is the first-line targeted therapeutic drug for HER2-positive breast cancer, leading to improved overall survival. However, acquired resistance inevitably occurs. We aimed to identify, quantify, and assess the mechanisms of acquired resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::ccfd1d5399c893609b303d2859eee706
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4236

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Autocrine CCL5 effect mediates trastuzumab resistance by ERK pathway activation in HER2-positive breast cancer

Autor: Zazo S, Gonzalez-Alonso P, Martin-Aparicio E, Chamizo C, Luque M, Sanz-Alvarez M, Minguez P, Gomez-Lopez G, Cristobal I, Carames C, Garcia-Foncillas J, Eroles P, Lluch A, Arpi O, Rovira A, Albanell J, Madoz-Gurpide J, Rojo F

Publikováno v: MOLECULAR CANCER THERAPEUTICS
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname

HER2-positive breast cancer is currently managed with chemotherapy in combination with specific anti-HER2 therapies, including trastuzumab. However, a high percentage of patients with HER2-positive tumors do not respond to trastuzumab (primary resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::d3a0ae64ea01e1c92d9da343bed95c2d
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4444

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Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-small ka, CyrillicB target genes in human breast cancer

Autor: Dalmases, A., Gonzalez, I., Menendez, S., Arpi, O., Corominas, J., Servitja, S., Tusquets, I., Chamizo, C., Rincon, R., Espinosa, L., Bigas, A., Eroles, P., Furriol, J., Lluch, A., Rovira, A., Albanell, J., Rojo, F.

Publikováno v: Oncotarget, 5, 1, pp. 196-210
Oncotarget, 5, 196-210

Item does not contain fulltext NF-small ka, CyrillicB has been linked to doxorubicin resistance in breast cancer patients. NF-small ka, CyrillicB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::141ac83cc701c879e0a5dc2d87870c97
https://hdl.handle.net/2066/137746

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Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-?B target genes in human breast cancer

Autor: Dalmases A, González I, Menendez S, Arpí O, Corominas JM, Servitja S, Tusquets I, Chamizo C, Rincón R, Espinosa L, Bigas A, Eroles P, Furriol J, Lluch A, Rovira A, Albanell J, Rojo F

Publikováno v: Oncotarget
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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NF-?B has been linked to doxorubicin resistance in breast cancer patients. NF-?B nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional relevance at transcriptional leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::97b5f7b9d6ea116e7ce8c5fcc2925dc7
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1543

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Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer

Autor: García-Parra J, Dalmases A, Morancho B, Arpí O, Menendez S, Sabbaghi M, Zazo S, Chamizo C, Madoz J, Eroles P, Servitja S, Tusquets I, Yelamos J, Lluch A, Arribas J, Rojo F, Rovira A, Albanell J

Publikováno v: European journal of cancer (Oxford, England : 1990)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising results in Breast Cancer (BRCA) deficient breast cancer, but not in molecularly unselected patient populations. Two lines of research in this field are needed: the identification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::f3ac958b42e15dec67716e113405c854
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1539

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