Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice▪

Autor: Santos, Edna J., Akbarali, Hamid I., Bow, Eric W., Chambers, Dana R., Gutman, Eugene S., Jacobson, Arthur E., Kang, Minho, Lee, Young K., Lutz, Joshua A., Rice, Kenner C., Sulima, Agnieszka, Negus, S. Stevens

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; November 2024, Vol. 391 Issue: 2 p138-151, 14p

A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.

Autor: Chambers, Dana R.¹ (AUTHOR), Sulima, Agnieszka¹ (AUTHOR), Luo, Dan² (AUTHOR), Prisinzano, Thomas E.² (AUTHOR), Goldberg, Alexander³ (AUTHOR), Xie, Bing³ (AUTHOR), Shi, Lei³ (AUTHOR), Paronis, Carol A.⁴ (AUTHOR), Bergman, Jack⁴ (AUTHOR), Nassehi, Nima⁵ (AUTHOR), Selley, Dana E.⁵ (AUTHOR), Imler, Gregory H.⁶ (AUTHOR), Jacobson, Arthur E.¹ (AUTHOR) arthurj@nida.nih.gov, Rice, Kenner C.¹ (AUTHOR) arthurj@nida.nih.gov

Publikováno v: Molecules. Oct2022, Vol. 27 Issue 19, p6455. 29p.

Efficacy As A Determinant Of Mu Opioid Receptor (MOR) Analgesic Effects In A Novel Assay Of Pain-Depressed Behavior In Mice. Ii. Effects Of Novel Low-Efficacy MOR Agonists

Autor: Santos, Edna J., Nassehi, Neema, Bow, Eric W., Chambers, Dana R., Gutman, Eugene S., Jacobson, Arthur E., Lutz, Joshua A., Rice, Kenner C., Sulima, Agnieszka, Selley, Dana E., Lee, Young K., Negus, Sidney S.

Publikováno v: In The Journal of Pain April 2023 24(4) Supplement:26-26

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