Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chamandi S. Dampalla"'
Autor:
Yunjeong Kim, Emma Pool, Eunji Kim, Chamandi S. Dampalla, Harry Nhat Nguyen, David K. Johnson, Scott Lovell, William C. Groutas, Kyeong-Ok Chang
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTFoot-and-mouth disease (FMD) is one of the most devastating diseases of livestock which can cause significant economic losses, especially when introduced to FMD-free countries. FMD virus (FMDV) belongs to the family Picornaviridae and is anti
Externí odkaz:
https://doaj.org/article/7ad3fe15365b43abbcf77691f2b8c7d8
Autor:
Pengfei Li, Yunjeong Kim, Chamandi S. Dampalla, Harry Nhat Nguyen, David K. Meyerholz, David K. Johnson, Scott Lovell, William C. Groutas, Stanley Perlman, Kyeong-Ok Chang
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic betacoronaviruses that continue to have a significant impact on public health. Timely development and intro
Externí odkaz:
https://doaj.org/article/f79fb18ff28149f79f0191d924e8bd47
Autor:
Chamandi S. Dampalla, Harry Nhat Nguyen, Athri D. Rathnayake, Yunjeong Kim, Krishani Dinali Perera, Trent K. Madden, Hayden A. Thurman, Alexandra J. Machen, Maithri M. Kashipathy, Lijun Liu, Kevin P. Battaile, Scott Lovell, Kyeong-Ok Chang, William C. Groutas
Publikováno v:
ACS Pharmacology & Translational Science. 6:181-194
Autor:
Scott Lovell, Harry Nhat Nguyen, Kyeong-Ok Chang, Kevin P. Battaile, Jian Zheng, Stanley Perlman, Matthew A. Baird, Maithri M. Kashipathy, Naemi Bickmeier, Chamandi S Dampalla, A.D. Rathnayake, William C. Groutas, Yunjeong Kim
Publikováno v:
Journal of Medicinal Chemistry
A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit severe acute respiratory s
Autor:
Chamandi S. Dampalla, Matthew J. Miller, Yunjeong Kim, Alexandria Zabiegala, Harry Nhat Nguyen, Trent K. Madden, Hayden A. Thurman, Alexandra J. Machen, Anne Cooper, Lijun Liu, Kevin P. Battaile, Scott Lovell, Kyeong-Ok Chang, William C. Groutas
Publikováno v:
European Journal of Medicinal Chemistry. 254:115376
Autor:
Chamandi S. Dampalla, Athri D. Rathnayake, Anushka C. Galasiti Kankanamalage, Yunjeong Kim, Krishani Dinali Perera, Harry Nhat Nguyen, Matthew J. Miller, Trent K. Madden, Hunter R. Picard, Hayden A. Thurman, Maithri M. Kashipathy, Lijun Liu, Kevin P. Battaile, Scott Lovell, Kyeong-Ok Chang, William C. Groutas
Publikováno v:
Journal of medicinal chemistry. 65(11)
The worldwide impact of the ongoing COVID-19 pandemic on public health has made imperative the discovery and development of direct-acting antivirals aimed at targeting viral and/or host targets. SARS-CoV-2 3C-like protease (3CL
Autor:
William C. Groutas, Harry Nhat Nguyen, Chamandi S Dampalla, A.D. Rathnayake, Yunjeong Kim, Kyeong-Ok Chang, Kevin P. Battaile, Maithri M. Kashipathy, Scott Lovell, Abdul-Rahman M Jesri, Gerald H. Lushington
Publikováno v:
Journal of Medicinal Chemistry. 63:11945-11963
Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, and children. The current lack
Autor:
Chamandi S. Dampalla, Athri D. Rathnayake, Krishani Dinali Perera, Abdul-Rahman M. Jesri, Harry Nhat Nguyen, Matthew J. Miller, Hayden A. Thurman, Jian Zheng, Maithri M. Kashipathy, Kevin P. Battaile, Scott Lovell, Stanley Perlman, Yunjeong Kim, William C. Groutas, Kyeong-Ok Chang
Publikováno v:
Journal of Medicinal Chemistry
The COVID-19 pandemic is having a major impact on public health worldwide, and there is an urgent need for the creation of an armamentarium of effective therapeutics, including vaccines, biologics, and small-molecule therapeutics, to combat SARS-CoV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51a7bd5b2eaf1d1a78a398192a7e815
https://doi.org/10.26434/chemrxiv.14781567
https://doi.org/10.26434/chemrxiv.14781567
Autor:
Krishani Dinali Perera, Yunjeong Kim, Stanley Perlman, Lok-Yin Roy Wong, Kevin P. Battaile, Chamandi S Dampalla, William C. Groutas, Kyeong-Ok Chang, Scott Lovell, Jian Zheng, Maithri M. Kashipathy, Harry Nhat Nguyen, David K. Meyerholz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Protease inhibitors targeting viral 3C-like protease are attractive therapeutic options for COVID-19. Here, we synthesized deuterated variants of a coronavirus protease inhibitor, GC376, and determined the therapeutic efficacy in a letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e465e62866d5759c0bf1b322ee6498
https://doi.org/10.1101/2021.02.05.429937
https://doi.org/10.1101/2021.02.05.429937