Two versus Three Infusion Regimens of N-Acetylcysteine for Acetaminophen Overdose

Autor: Shadi Tamur, Bader Alyahya, Faisal Alsani, Ammar Abdulraheem Bahauddin, Maryam Aljaid, Sultan Al-Malki, Ahmad Alzahrani, Abdullah Khayat, Anwar Shams, Dominic S. Chalut

Publikováno v: Pediatric Reports, Vol 16, Iss 1, Pp 232-242 (2024)

Background: Acetaminophen overdose is a common clinical condition, often leading to liver toxicity. Current treatments involve the three-infusion N-Acetylcysteine (NAC) regimen (FDA-labeled), which may be complex, time-consuming, and need to be chang

Externí odkaz: https://doaj.org/article/4b3cd0f9fc5f4ef3990e1faae3c101c3

Plakoglobin is a mechanoresponsive regulator of naive pluripotency

Autor: Timo N. Kohler, Joachim De Jonghe, Anna L. Ellermann, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Antonia Weberling, Clara Munger, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs will provide insight into mechanisms underlying mammalian pre-imp

Externí odkaz: https://doaj.org/article/19d37a4e6ae24ca8b14f83a6a064a669

The Green Edge cruise: investigating the marginal ice zone processes during late spring and early summer to understand the fate of the Arctic phytoplankton bloom

Autor: F. Bruyant, R. Amiraux, M.-P. Amyot, P. Archambault, L. Artigue, L. Barbedo de Freitas, G. Bécu, S. Bélanger, P. Bourgain, A. Bricaud, E. Brouard, C. Brunet, T. Burgers, D. Caleb, K. Chalut, H. Claustre, V. Cornet-Barthaux, P. Coupel, M. Cusa, F. Cusset, L. Dadaglio, M. Davelaar, G. Deslongchamps, C. Dimier, J. Dinasquet, D. Dumont, B. Else, I. Eulaers, J. Ferland, G. Filteau, M.-H. Forget, J. Fort, L. Fortier, M. Galí, M. Gallinari, S.-E. Garbus, N. Garcia, C. Gérikas Ribeiro, C. Gombault, P. Gourvil, C. Goyens, C. Grant, P.-L. Grondin, P. Guillot, S. Hillion, R. Hussherr, F. Joux, H. Joy-Warren, G. Joyal, D. Kieber, A. Lafond, J. Lagunas, P. Lajeunesse, C. Lalande, J. Larivière, F. Le Gall, K. Leblanc, M. Leblanc, J. Legras, K. Lévesque, K.-M. Lewis, E. Leymarie, A. Leynaert, T. Linkowski, M. Lizotte, A. Lopes dos Santos, C. Marec, D. Marie, G. Massé, P. Massicotte, A. Matsuoka, L. A. Miller, S. Mirshak, N. Morata, B. Moriceau, P.-I. Morin, S. Morisset, A. Mosbech, A. Mucci, G. Nadaï, C. Nozais, I. Obernosterer, T. Paire, C. Panagiotopoulos, M. Parenteau, N. Pelletier, M. Picheral, B. Quéguiner, P. Raimbault, J. Ras, E. Rehm, L. Ribot Lacosta, J.-F. Rontani, B. Saint-Béat, J. Sansoulet, N. Sardet, C. Schmechtig, A. Sciandra, R. Sempéré, C. Sévigny, J. Toullec, M. Tragin, J.-É. Tremblay, A.-P. Trottier, D. Vaulot, A. Vladoiu, L. Xue, G. Yunda-Guarin, M. Babin

Publikováno v: Earth System Science Data, Vol 14, Pp 4607-4642 (2022)

The Green Edge project was designed to investigate the onset, life, and fate of a phytoplankton spring bloom (PSB) in the Arctic Ocean. The lengthening of the ice-free period and the warming of seawater, amongst other factors, have induced major chan

Externí odkaz: https://doaj.org/article/a4c3fafbe88743e18c0a2e61893ef290

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Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids.

Autor: Stephen Adonai Leon-Icaza, Salimata Bagayoko, Romain Vergé, Nino Iakobachvili, Chloé Ferrand, Talip Aydogan, Célia Bernard, Angelique Sanchez Dafun, Marlène Murris-Espin, Julien Mazières, Pierre Jean Bordignon, Serge Mazères, Pascale Bernes-Lasserre, Victoria Ramé, Jean-Michel Lagarde, Julien Marcoux, Marie-Pierre Bousquet, Christian Chalut, Christophe Guilhot, Hans Clevers, Peter J Peters, Virginie Molle, Geanncarlo Lugo-Villarino, Kaymeuang Cam, Laurence Berry, Etienne Meunier, Céline Cougoule

Publikováno v: PLoS Pathogens, Vol 19, Iss 8, p e1011559 (2023)

Mycobacterium abscessus (Mabs) drives life-shortening mortality in cystic fibrosis (CF) patients, primarily because of its resistance to chemotherapeutic agents. To date, our knowledge on the host and bacterial determinants driving Mabs pathology in

Externí odkaz: https://doaj.org/article/dd6af14953434ec98b532b99ba43fe5d