Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chalonda R. Handy"'
Autor:
Eleanor M. Donnelly, Eric T. Quach, Terence M. Hillery, Brenten L. Heeke, Brooke R. Snyder, Chalonda R. Handy, Deirdre M. O'Connor, Nicholas M. Boulis, Thais Federici
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Externí odkaz:
https://doaj.org/article/8b865ceb2cc341f8b50a0739c7a8b385
Publikováno v:
Neurology Research International, Vol 2011 (2011)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive loss of motor neurons, muscle wasting, and respiratory dysfunction. With disease progression, secondary symptoms arise creating new problematic conditions
Externí odkaz:
https://doaj.org/article/fc3810b848104282bcca918e22c4b95d
Autor:
Eleanor M. Donnelly, Chalonda R. Handy, Nicholas M. Boulis, Prasanna Kumar, Emily M. Barrow, Qingshan Teng, Christina Krudy, Dean Cress, Thais Federici, Colin K. Franz
Publikováno v:
Neurosurgery. 72:653-661
BACKGROUND Neuromodulation is used to restore neural function in disorders that stem from an imbalance in the activity of specific neural networks when they prove refractory to pharmacological therapy. The Kir2.1 gene contributes to stabilizing the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe46e2b91b1e711ea065c83b2a4c2ff
https://doi.org/10.1227/neu.0b013e318283f59a
https://doi.org/10.1227/neu.0b013e318283f59a
Autor:
Eric T. Quach, Thais Federici, Nicholas M. Boulis, Chalonda R. Handy, Eleanor M. Donnelly, Brooke R. Snyder, Brenten L. Heeke, Deirdre M. O’Connor, Terence M. Hillery
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee5215143faed197d6e55950fa4c593
http://www.sciencedirect.com/science/article/pii/S0969996111003937
http://www.sciencedirect.com/science/article/pii/S0969996111003937
Autor:
Steven J. Gray, Richard Jude Samulski, Marco A. Passini, K A Matthews, Chalonda R. Handy, Thais Federici, Jason Taub, Joshua C Grieger, Griffin R. Baum, Nicholas M. Boulis
Publikováno v:
Gene Therapy. 19:852-859
Adeno-associated viral vector 9 (AAV9) has recently been shown to penetrate the blood–brain barrier via intravascular administration, making it a good candidate for diffuse gene delivery. However, the potential side effects of systemic delivery are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cef131364211af38b1fa3d8dcf78c1
https://doi.org/10.1038/gt.2011.130
https://doi.org/10.1038/gt.2011.130
Publikováno v:
Neurology Research International
Neurology Research International, Vol 2011 (2011)
Neurology Research International, Vol 2011 (2011)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive loss of motor neurons, muscle wasting, and respiratory dysfunction. With disease progression, secondary symptoms arise creating new problematic conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89896c09c77b118503e37e2e02a37b4
https://doi.org/10.1155/2011/403808
https://doi.org/10.1155/2011/403808
Autor:
Jonathan A. Fidler, Jennifer C Matthews, Meghan Rao, Amy Eagle, Christopher M. Treleaven, Brian K. Kaspar, Chalonda R. Handy, Tatyana V. Taksir, Seng H. Cheng, Amanda M. Haidet, Mark E. Hester, Lamya S. Shihabuddin, James Dodge
Publikováno v:
Molecular Therapy. 18:2075-2084
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron cell death in the cortex, brainstem, and spinal cord. Extensive efforts have been made to develop trophic factor-based therapies to enhance motor n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f44cc3653c4ab8049a3a76a6597488d
https://doi.org/10.1038/mt.2010.206
https://doi.org/10.1038/mt.2010.206
Autor:
Brian K. Kaspar, Louise R. Rodino-Klapac, Janaiah Kota, Chalonda R. Handy, Amanda M. Haidet, Jerry R. Mendell
Publikováno v:
Muscle & Nerve. 39:283-296
In most cases, pharmacologic strategies to treat genetic muscle disorders and certain acquired disorders, such as sporadic inclusion body myositis, have produced modest clinical benefits. In these conditions, inhibition of the myostatin pathway repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9eb0b5b384df1739186ef65fdb1061
https://doi.org/10.1002/mus.21244
https://doi.org/10.1002/mus.21244
Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice
Autor:
Chien Liang Glenn Lin, Joseph B. Travers, Yuan Lin, Robert L. Stephens, Guilian Tian, Chalonda R. Handy, Kenny Roman
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G129-G134
Visceral hypersensitivity is the leading complaint of functional bowel disorders. Central sensitization mediated by glutamate receptor activation is implicated in pathophysiology of visceral pain. The glial glutamate transporter EAAT2 is the principa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2d26c80d963a655b1a8b0668dc387a
https://doi.org/10.1152/ajpgi.90556.2008
https://doi.org/10.1152/ajpgi.90556.2008
Publikováno v:
Pain Research and Treatment
Pain Research and Treatment, Vol 2011 (2011)
Pain Research and Treatment, Vol 2011 (2011)
Chronic pain is experienced by as many as of cancer patients at some point during the disease. This pain can be directly cancer related or arise from a sensory neuropathy related to chemotherapy. Major pharmacological agents used to treat cancer pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694d077043057a1f94a95559d0c505d1
http://europepmc.org/articles/PMC3196247
http://europepmc.org/articles/PMC3196247