Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

Autor: Brignell, JL, Perry, MD, Nelson, CP, Willets, JM, Challiss, RAJ, Davies, NW

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121285 (2015)

Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::47acd9ece931f11aa03f450729f4422f
https://irep.ntu.ac.uk/id/eprint/2886/1/220835_PubSub2661_Nelson.pdf

GRK2 expression and catalytic activity are essential for vasoconstrictor/ERK-stimulated arterial smooth muscle proliferation.

Autor: Alonazi A; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, United Kingdom; Department of Pharmacology and Toxicology, Pharmacy College, King Saud University, Riyadh, P.O. Box 145111, Saudi Arabia(1)., Nash CA; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, United Kingdom; Cardiovascular Metabolism, Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA 02139, USA., Wang CH; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, United Kingdom., Christofidou E; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, United Kingdom; Tumor Viruses and Cancer Laboratory, Department of Biological Sciences, University of Cyprus, Panepistimiou 1, Aglantzia 2109, Nicosia, Cyprus(1)., Challiss RAJ; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, United Kingdom., Willets JM; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, United Kingdom. Electronic address: jmw23@le.ac.uk.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2023 Oct; Vol. 216, pp. 115795. Date of Electronic Publication: 2023 Sep 09.

Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions.

Autor: Rainbow RD; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Brennan S; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Jackson R; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Beech AJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Bengreed A; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Waldschmidt HV; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Tesmer JJG; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Challiss RAJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.)., Willets JM; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom (A.B., R.A.J.C., J.M.W.); Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, United Kingdom (R.D.R., S.B., R.J., A.J.B.); Life Sciences Institute and Departments of Pharmacology, Biological Sciences, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan (H.V.W., J.J.G.T.); and Department of Biological Sciences, Purdue University, West Lafayette, Indiana (J.J.G.T.) jmw23@leicester.ac.uk.

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2018 Sep; Vol. 94 (3), pp. 1079-1091. Date of Electronic Publication: 2018 Jul 06.

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.

Autor: Robinson SW; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Bourgognon JM; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Spiers JG; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Breda C; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Campesan S; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Butcher A; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Mallucci GR; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom., Dinsdale D; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Morone N; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Mistry R; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Smith TM; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Guerra-Martin M; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom., Challiss RAJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Giorgini F; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Steinert JR; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom.

Publikováno v: PLoS biology [PLoS Biol] 2018 Apr 09; Vol. 16 (4), pp. e2003611. Date of Electronic Publication: 2018 Apr 09 (Print Publication: 2018).