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Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.

Autor: Giannangelo, Carlo, Challis, Matthew P., Siddiqui, Ghizal, Edgar, Rebecca, Malcolm, Tess R., Webb, Chaille T., Drinkwater, Nyssa, Vinh, Natalie, Macraild, Christopher, Counihan, Natalie, Duffy, Sandra, Wittlin, Sergio, Devine, Shane M., Avery, Vicky M., De Koning-Ward, Tania, Scammells, Peter, McGowan, Sheena, Creek, Darren J.

Publikováno v: eLife; 7/8/2024, p1-32, 32p

Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon.

Autor: Wu Y; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Foollee A; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Chan AY; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Hille S; Department of Internal Medicine V, University Hospital of Schleswig-Holstein, Campus Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Hauke J; Division of Inherited Metabolic Diseases, University Children's Hospital, Heidelberg, Germany., Challis MP; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Johnson JL; Meyer Cancer Center, Weill Cornell Medicine, New York, USA.; Department of Cell Biology, Harvard Medical School, Boston, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA., Yaron TM; Meyer Cancer Center, Weill Cornell Medicine, New York, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, USA.; Columbia University Vagelos College of Physicians and Surgeons, New York, USA., Mynard V; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Aung OH; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Cleofe MAS; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Huang C; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia.; Monash Proteomics and Metabolomics Platform, Monash University, Victoria, Australia., Lim Kam Sian TCC; Monash Proteomics and Metabolomics Platform, Monash University, Victoria, Australia., Rahbari M; German Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Im Neuenheimer Feld 280, Heidelberg, Germany.; University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Department of Surgery, Theodor-Kutzer-Ufer 1-3, Heidelberg, Germany.; University Tuebingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Otfried-Müller-Straße 37, Tübingen, Germany., Gallage S; German Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Im Neuenheimer Feld 280, Heidelberg, Germany.; University Tuebingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Otfried-Müller-Straße 37, Tübingen, Germany., Heikenwalder M; German Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Im Neuenheimer Feld 280, Heidelberg, Germany.; University Tuebingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Otfried-Müller-Straße 37, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard-Karls University, Tübingen, Germany., Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, USA.; Department of Cell Biology, Harvard Medical School, Boston, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA., Schittenhelm RB; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia.; Monash Proteomics and Metabolomics Platform, Monash University, Victoria, Australia., Formosa LE; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Smith GC; School of Biomedical Sciences, University of New South Wales, Sydney, Australia., Okun JG; Division of Inherited Metabolic Diseases, University Children's Hospital, Heidelberg, Germany., Müller OJ; Department of Internal Medicine V, University Hospital of Schleswig-Holstein, Campus Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Rusu PM; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Rose AJ; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia. adam.rose@monash.edu.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia. adam.rose@monash.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8390. Date of Electronic Publication: 2024 Sep 27.