Brazilin is a natural product inhibitor of the NLRP3 inflammasome

Autor: McMahon, Emily, El-Sayed, Sherihan, Green, Jack, Hoyle, Christopher, FitzPatrick, Lorna, Jones, Emma V., Corrie, Eve, Kelly, Rebecca L., Challinor, Mairi, Freeman, Sally, Bryce, Richard A., Lawrence, Catherine B., Brough, David, Kasher, Paul R.

Publikováno v: In iScience 16 February 2024 27(2)

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth

Autor: Smithen, Deborah A., Leung, Leo M. H., Challinor, Mairi, Lawrence, Rae, Tang, HaoRan, Niculescu-Duvaz, Dan, Pearce, Simon P., Mcleary, Robert, Lopes, Filipa, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Thomson, Graeme, Marais, Richard, Springer, Caroline

Publikováno v: Journal of Medicinal Chemistry

The lysyl oxidase (LOX) family of extracellular proteins plays a vital role in catalyzing the formation of cross-links in fibrillar elastin and collagens leading to extracellular matrix (ECM) stabilization. These enzymes have also been implicated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::280ebdb4ed1090eb12b072926cba2a0a
http://europepmc.org/articles/PMC7073924

Regulation of RUNX1 dosage is crucial for efficient blood formation from Hemogenic Endothelium

Autor: Lie-A-Ling, Michael, Marinopoulou, Elli, Lilly, Andrew J., Challinor, Mairi, Patel, Rahima, Lancrin, Christophe, Kouskoff, Valerie, Lacaud, Georges

Publikováno v: Lie-A-Ling, M, Marinopoulou, E, Lilly, A J, Challinor, M, Patel, R, Lancrin, C, Kouskoff, V & Lacaud, G 2018, ' Regulation of RUNX1 dosage is crucial for efficient blood formation from Hemogenic Endothelium ', Development . https://doi.org/10.1242/dev.149419
Development (Cambridge, England)

During ontogeny, hematopoietic stem and progenitor cells arise from hemogenic endothelium through an endothelial-to-hematopoietic transition that is strictly dependent on the transcription factor RUNX1. Although it is well established that RUNX1 is e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::163a3973604ba229d13f3d433f342cb3
https://research.manchester.ac.uk/en/publications/398d09dc-3795-4a92-be39-e51ff1440044

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation

Autor: Goode, Debbie K., Obier, Nadine, Vijayabaskar, M.S., Lie-A-Ling, Michael, Lilly, Andrew J., Hannah, Rebecca, Lichtinger, Monika, Batta, Kiran, Florkowska, Magdalena, Patel, Rahima, Challinor, Mairi, Wallace, Kirstie, Gilmour, Jane, Assi, Salam A., Cauchy, Pierre, Hoogenkamp, Maarten, Westhead, David R., Lacaud, Georges, Kouskoff, Valerie, Göttgens, Berthold, Bonifer, Constanze

Publikováno v: Developmental Cell
Goode, D K, Obier, N, Vijayabaskar, M S, Lie-A-Ling, M, Lilly, A, Hannah, R, Lichtinger, M, Batta, K, Florkowska, M, Patel, R, Challinor, M, Wallace, K, Gilmour, J, Assi, S A, Cauchy, P, Hoogenkamp, M, Westhead, D R, Lacaud, G, Kouskoff, V, Göttgens, B & Bonifer, C 2016, ' Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation ', Developmental cell, vol. 36, no. 5, pp. 572-587 . https://doi.org/10.1016/j.devcel.2016.01.024

Summary Metazoan development involves the successive activation and silencing of specific gene expression programs and is driven by tissue-specific transcription factors programming the chromatin landscape. To understand how this process executes an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a0882ce8c4a37ab14b23d247967f9e08
https://eprints.whiterose.ac.uk/96518/8/1-s2.0-S1534580716300028-main.pdf

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