Detecting RNA base methylations in single cells by in situ hybridization

Autor: Ranasinghe, Rohan T, Challand, Martin R, Ganzinger, Kristina A, Lewis, Benjamin W, Softley, Charlotte, Schmied, Wolfgang H, Horrocks, Mathew H, Shivji, Nadia, Chin, Jason W, Spencer, James, Klenerman, David

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Ranasinghe, R T, Challand, M R, Ganzinger, K A, Lewis, B W, Softley, C, Schmied, W H, Horrocks, M H, Shivji, N, Chin, J W, Spencer, J & Klenerman, D 2018, ' Detecting RNA base methylations in single cells by in situ hybridization ', Nature Communications, vol. 9, no. 1, 655 . https://doi.org/10.1038/s41467-017-02714-7
Nature Communications
Ranasinghe, R T, Challand, M R, Ganzinger, K A, Lewis, B W, Softley, C, Schmied, W H, Horrocks, M H, Shivji, N, Chin, J W, Spencer, J & Klenerman, D 2018, ' Detecting RNA base methylations in single cells by in situ hybridization ', Nature Communications, vol. 9, 655 . https://doi.org/10.1038/s41467-017-02714-7

Methylated bases in tRNA, rRNA and mRNA control a variety of cellular processes, including protein synthesis, antimicrobial resistance and gene expression. Currently, bulk methods that report the average methylation state of ~104–107 cells are used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a317e78d7845c95d24cbce96d37f0a57
https://doaj.org/article/681a36aec6e7448383e2cd2cf34e6586

Cysteine Methylation Controls Radical Generation in the Cfr Radical AdoMet rRNA Methyltransferase.

Autor: Challand, Martin R.¹, Salvadori, Enrico^2,3, Driesener, Rebecca C.⁴, Kay, Christopher W. M.^2,3 c.kay@ucl.ac.uk, Roach, Peter L.^4,5 p.l.roach@soton.ac.uk, Spencer, James¹ Jim.Spencer@bristol.ac.uk

Publikováno v: PLoS ONE. Jul2013, Vol. 8 Issue 7, p1-10. 10p.

Product inhibition in the radical S-adenosylmethionine family

Autor: Challand, Martin R., Ziegert, Tillman, Douglas, Paul, Wood, Robert J., Kriek, Marco, Shaw, Nicholas M., Roach, Peter L.

Publikováno v: In FEBS Letters 2009 583(8):1358-1362

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