Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function.

Autor: Swamynathan MM; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.; Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY 11794, USA., Kuang S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Watrud KE; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Doherty MR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Gineste C; Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, Inserm U1258, Strasbourg University, Illkirch CEDEX 67404, France., Mathew G; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.; Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA., Gong GQ; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Cox H; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Cheng E; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Reiss D; Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, Inserm U1258, Strasbourg University, Illkirch CEDEX 67404, France., Kendall J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Ghosh D; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Reczek CR; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Zhao X; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Herzka T; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Špokaitė S; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Dessus AN; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Kim ST; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.; Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY 11794, USA., Klingbeil O; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Liu J; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA., Nowak DG; Department of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA.; Division of Hematology and Medical Oncology, Department of Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA., Alsudani H; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Wee TL; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Park Y; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Minicozzi F; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Rivera K; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Almeida AS; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.; APC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 K8AF, Ireland., Chang K; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Chakrabarty RP; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wilkinson JE; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Gimotty PA; Perelman School of Medicine, Division of Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA., Diermeier SD; Department of Biochemistry, University of Otago, Dunedin 9016, New Zealand., Egeblad M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.; School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Vakoc CR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Locasale JW; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA., Chandel NS; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Janowitz T; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Hicks JB; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.; Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA 90089, USA., Wigler M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Pappin DJ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Williams RL; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Cifani P; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Tuveson DA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA., Laporte J; Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, Inserm U1258, Strasbourg University, Illkirch CEDEX 67404, France., Trotman LC; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Oct 25; Vol. 386 (6720), pp. eadk9167. Date of Electronic Publication: 2024 Oct 25.

A Drosophila model of mitochondrial disease phenotypic heterogeneity.

Autor: Granat L; Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London SE5 9RX, UK., Knorr DY; Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London SE5 9RX, UK., Ranson DC; Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London SE5 9RX, UK., Chakrabarty RP; Department of Medicine, Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Chandel NS; Department of Medicine, Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Bateman JM; Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London SE5 9RX, UK.

Publikováno v: Biology open [Biol Open] 2024 Feb 15; Vol. 13 (2). Date of Electronic Publication: 2024 Feb 28.

Mitochondrial integrated stress response controls lung epithelial cell fate.

Autor: Han S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA. shan@northwestern.edu., Lee M; Department of Life Science, Dongguk University-Seoul, Goyang-si, Republic of Korea., Shin Y; Department of Life Science, Dongguk University-Seoul, Goyang-si, Republic of Korea., Giovanni R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Chakrabarty RP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Herrerias MM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Dada LA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Flozak AS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Reyfman PA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Khuder B; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Reczek CR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Gao L; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Seville, Spain., Lopéz-Barneo J; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Seville, Spain., Gottardi CJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Budinger GRS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA., Chandel NS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA. nav@northwestern.edu.; Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA. nav@northwestern.edu.

Publikováno v: Nature [Nature] 2023 Aug; Vol. 620 (7975), pp. 890-897. Date of Electronic Publication: 2023 Aug 09.

DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs.

Autor: Robertson GL; Vanderbilt University, Cell and Developmental Biology, Nashville, TN 37232, USA., Riffle S; Vanderbilt University, Cell and Developmental Biology, Nashville, TN 37232, USA., Patel M; Vanderbilt University, Cell and Developmental Biology, Nashville, TN 37232, USA., Bodnya C; Vanderbilt University, Cell and Developmental Biology, Nashville, TN 37232, USA., Marshall A; Vanderbilt University, Molecular Physiology and Biophysics, Nashville, TN 37232, USA., Beasley HK; Vanderbilt University, Molecular Physiology and Biophysics, Nashville, TN 37232, USA., Garza-Lopez E; Vanderbilt University, Molecular Physiology and Biophysics, Nashville, TN 37232, USA., Shao J; Central Microscopy Research Facility, University of Iowa, Iowa City, IA 52246, USA., Vue Z; Vanderbilt University, Molecular Physiology and Biophysics, Nashville, TN 37232, USA., Hinton A; Vanderbilt University, Molecular Physiology and Biophysics, Nashville, TN 37232, USA., Stoll MS; Case Western Reserve University, Department of Pharmacology and Center for Mitochondrial Diseases, Cleveland, OH 44106, USA., de Wet S; Stellenbosch University, Department of Physiological Sciences, Matieland, 7602, Stellenbosch, South Africa., Theart RP; Stellenbosch University, Department of Electrical and Electronic Engineering, Matieland, 7602, Stellenbosch, South Africa., Chakrabarty RP; Northwestern University, Feinberg School of Medicine Department of Medicine Division of Pulmonary and Critical Care Medicine, Chicago, IL 60611, USA., Loos B; Stellenbosch University, Department of Electrical and Electronic Engineering, Matieland, 7602, Stellenbosch, South Africa., Chandel NS; Northwestern University, Feinberg School of Medicine Department of Medicine Division of Pulmonary and Critical Care Medicine, Chicago, IL 60611, USA.; Northwestern University, Feinberg School of Medicine Department of Biochemistry and Molecular Genetics, Chicago, IL 60611, USA., Mears JA; Case Western Reserve University, Department of Pharmacology and Center for Mitochondrial Diseases, Cleveland, OH 44106, USA., Gama V; Vanderbilt University, Cell and Developmental Biology, Nashville, TN 37232, USA.; Vanderbilt University, Vanderbilt Center for Stem Cell Biology, Nashville, TN 37232, USA.; Vanderbilt University, Vanderbilt Brain Institute, Nashville, TN 37232, USA.

Publikováno v: Journal of cell science [J Cell Sci] 2023 Feb 01; Vol. 136 (3). Date of Electronic Publication: 2023 Feb 10.

DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting.

Autor: Yuskaitis CJ; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Division of Epilepsy and Clinical Neurophysiology and Epilepsy Genetics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Modasia JB; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Schrötter S; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Rossitto LA; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Groff KJ; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Morici C; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Mithal DS; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Section of Neurology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Chakrabarty RP; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Chandel NS; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Manning BD; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Sahin M; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA. Electronic address: mustafa.sahin@childrens.harvard.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Aug 30; Vol. 40 (9), pp. 111278.