Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chakkrapong Handumrongkul"'
Autor:
Timothy D. Heath, Robert J. Debs, Stephen Chmura, Alice Ye, Chakkrapong Handumrongkul, Sarah Ursu, Ron G. Rosenfeld
Publikováno v:
Journal of the Endocrine Society. 5:A550-A551
Recombinant human growth hormone (rhGH), the mainstay of hGH replacement therapy, is injected daily for years to enable children to achieve normal stature. Daily rhGH injections are required because its serum-T1/2 is 230 days; 2) Concurrently, hGH-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37da55879d29133f557f4549052e10ff
https://doi.org/10.1210/jendso/bvab048.1121
https://doi.org/10.1210/jendso/bvab048.1121
Autor:
Stephen Chmura, Yong Liu, Ryan J Ice, David B. Lewis, Liliana Soroceanu, Alice L. Ye, Robert Thistle, Denny Liggitt, Methawee Myers, Chakkrapong Handumrongkul, Mohammed Kashani-Sabet, Robert J. Debs, Sarah Ursu, Marissa Mack, Timothy D. Heath
Publikováno v:
Science Advances
HEDGES, a tunable nonviral DNA-based gene therapy platform, durably expresses human therapeutic proteins in immunocompetent mice.
Recombinant adeno-associated virus (AAV) vectors are transforming therapies for rare human monogenic deficiency dis
Recombinant adeno-associated virus (AAV) vectors are transforming therapies for rare human monogenic deficiency dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a82e7e5a17981e499fb82dac6a28dd
https://pubmed.ncbi.nlm.nih.gov/31807699
https://pubmed.ncbi.nlm.nih.gov/31807699
Autor:
Fareedah Lawal, Valsamma Abraham, Robert J. Debs, Andrew Parambath, Chakkrapong Handumrongkul, Horace M. DeLisser, Gaoyuan Cao
Publikováno v:
International Journal of Oncology
Platelet endothelial cell adhesion molecule‑1 (PECAM‑1) is expressed on the vascular endothelium and has been implicated in the late progression of metastatic tumors. The activity of PECAM‑1 appears to be mediated by modulation of the tumor mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7e2425d0c2c023530633bbc9409932
https://doi.org/10.3892/ijo.2018.4422
https://doi.org/10.3892/ijo.2018.4422
Autor:
Robert J. Debs, Chakkrapong Handumrongkul, Timothy D. Heath, H. Denny Liggitt, Steven W. Dow, Yong Liu
Publikováno v:
Journal of Biological Chemistry. 277:4966-4972
We have characterized the impact of strain-based genetic differences on the efficiency of the intravenous cationic liposome-DNA complex (CLDC)-based gene transfer and expression in mice. We also investigated what steps in the gene delivery and expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e186efa031d73920a3dc6afb4a77e04
https://doi.org/10.1074/jbc.m110285200
https://doi.org/10.1074/jbc.m110285200
Autor:
Pierre-Yves Desprez, Robert J. Debs, Sylvia Fong, Mehdi Nosrati, Ann D. Thor, Guanghuan Tu, Shuqing Liu, Chakkrapong Handumrongkul, Yong Liu, Denny Liggitt, Mohammed Kashani-Sabet
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(6)
To date, functional genomic studies have been confined to either cell-based assays or germline mutations, using transgenic or knockout animals. However, these approaches are often unable either to recapitulate complex biologic phenotypes, such as tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9079e6344042586e72eedb4502290260
https://pubmed.ncbi.nlm.nih.gov/11891271
https://pubmed.ncbi.nlm.nih.gov/11891271
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 5(2)
Gene transfection, a process used to study gene function, is itself poorly understood. Transfection-enhancing agents, including phorbol myristic acid (PMA) and histone deacetylase (HDAC) inhibitors, have been shown to increase transfection efficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d410e033090bb36cf77a1c0e48ebd6e7
https://pubmed.ncbi.nlm.nih.gov/11829526
https://pubmed.ncbi.nlm.nih.gov/11829526
Autor:
Bhavini Desai, Wendy Zhong, Robert J. Debs, Harshini V. de Silva, J M Taylor, Chakkrapong Handumrongkul, Elisabeth Tse, Leslie C. Mounkes
Publikováno v:
Human gene therapy. 12(16)
Germ line gene disruption and gene insertion are often used to study the function of selected genes in vivo. We used selected knockout and transgenic mouse models to attempt to identify lipoprotein-related genes and gene products that regulate the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acc9d2c7ba6feb31de92bc8291ebd4b
https://pubmed.ncbi.nlm.nih.gov/11686936
https://pubmed.ncbi.nlm.nih.gov/11686936
Autor:
Robert J. Debs, Mohammed Kashani-Sabet, Sylvia Fong, Christopher M. Haqq, Chakkrapong Handumrongkul, C. Collins, Mehdi Nosrati, Horace M. DeLisser, Bruce A. Keyt, Cory Nadel
Publikováno v:
Cancer Research. 72:2847-2847
Objectives: Patients who die from cancer succumb to advanced metastatic progression (AMP). While targeted therapies are available that address tumor cell derived regulators of metastasis, few therapeutics are being developed to address the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25580a36d352bb6f46556865fa7954df
https://doi.org/10.1158/1538-7445.am2012-2847
https://doi.org/10.1158/1538-7445.am2012-2847