Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chakkodabylu S. Ramesha"'
Publikováno v:
Journal of Biological Chemistry. 272:12393-12398
Prostaglandins are synthesized by prostaglandin H synthase (PGHS) 1 and 2. PGHS2 is regulated through inducible expression. We report here the regulation of PGHS1 activity by substrate-dependent cooperative activation. The cooperativity is characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e96f27cfdce24918e25adfecab23f6
https://doi.org/10.1074/jbc.272.19.12393
https://doi.org/10.1074/jbc.272.19.12393
Publikováno v:
Proceedings of the National Academy of Sciences. 90:4475-4479
The interaction of tumor necrosis factor alpha (TNF) with its two membrane-bound receptors initiates intracellular events in which arachidonic acid and its derivatives are involved. In HeLa cells, TNF treatment induces an arachidonic acid-selective,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaff45575a26917598dd042fde81fbec
https://doi.org/10.1073/pnas.90.10.4475
https://doi.org/10.1073/pnas.90.10.4475
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1168:37-44
The present report describes the presence of an arachidonic-acid-selective, dithiothreitol-insensitive phospholipase A2 enzyme activity in human neutrophil cytosol. The enzyme activity is eluted from Mono Q FPLC column between 350 to 450 mM salt and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0665d58a59ad0c3172e6de6fd0687adc
https://doi.org/10.1016/0005-2760(93)90263-9
https://doi.org/10.1016/0005-2760(93)90263-9
Publikováno v:
Analytical Biochemistry. 192:173-180
A simple gas chromatographic method for the assay of phospholipase A2 (PLA2) has been described in which arachidonic acid released from endogenous phospholipid pools is measured following its extraction and derivatization to pentafluorobenzyl esters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725a2e7936859529971956a4d96af13f
https://doi.org/10.1016/0003-2697(91)90203-6
https://doi.org/10.1016/0003-2697(91)90203-6
Autor:
Pamela Volkel, Yi-Zheng Xu, Martin Huber, Teresa Biegel, Chakkodabylu S. Ramesha, Simon W. Lee, Marie Dinh, Liliana E. Scarafia, Jim W. Barnett, Qing-Fen Gan, Amy Y. Mak, Stacie A. Dalrymple, On-Yee So, James Patrick Dunn, Mary Mulkins, David C. Swinney, Ina Lee
Publikováno v:
The Journal of biological chemistry. 277(26)
A small molecule inhibitor of NF-kappaB-dependent cytokine expression was discovered that blocked tumor necrosis factor (TNF) alpha-induced IkappaB(alpha) degradation in MM6 cells but not the degradation of beta-catenin in Jurkat cells. Ro106-9920 bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa26b171203043d8e1aa00e897eed2ae
https://pubmed.ncbi.nlm.nih.gov/11950839
https://pubmed.ncbi.nlm.nih.gov/11950839
Publikováno v:
The Journal of biological chemistry. 272(34)
Because of its structural similarity to polyunsaturated fatty acids, anandamide could serve as substrate for enzymes such as lipoxygenases and cyclooxygenases, which metabolize polyunsaturated fatty acids to potent bioactive metabolites. Here the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9397689f1be5345af43d6cbc10d575
https://pubmed.ncbi.nlm.nih.gov/9261124
https://pubmed.ncbi.nlm.nih.gov/9261124
Autor:
Chakkodabylu S. Ramesha
Publikováno v:
Drug Discovery Today. 5:43-44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cee92bd30d9c284d9a86a72c60b3031
https://doi.org/10.1016/s1359-6446(99)01444-0
https://doi.org/10.1016/s1359-6446(99)01444-0
Autor:
Chakkodabylu S. Ramesha, Lisa A. Sultzman, Nina Milona, Lih-Ling Lin, Ronald W. Kriz, James D. Clark, Alice Y. Lin, John L. Knopf
Publikováno v:
Cell. 65(6)
We report the cloning and expression of a cDNA encoding a high molecular weight (85.2 kd) cytosolic phospholipase A 2 (cPLA 2 ) that has no detectable sequence homology with the secreted forms of PLA 2 . We show that cPLA 2 selectively cleaves arachi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473c8cfca010c9a7b8e06c159903548a
https://pubmed.ncbi.nlm.nih.gov/1904318
https://pubmed.ncbi.nlm.nih.gov/1904318
Publisher Summary The chapter presents a study on quantitative analysis of platelet-activating factor (PAF) by gas chromatography-negative-ion chemical ionization mass spectrometry (GC-NCI-MS). One of the most promising of these PAF derivatives is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5bf58f2a915a348987cb17b127183b9
https://doi.org/10.1016/0076-6879(90)87019-y
https://doi.org/10.1016/0076-6879(90)87019-y
Publikováno v:
Biomedicalenvironmental mass spectrometry. 13(3)
A very sensitive method of 1-O-alkyl-2-acetyl-sn-glycerophosphocholine (platelet activating factor) quantitation is described. 1-O-Alkyl-2-acetyl-sn-glycerophosphocholine is converted to 1-O-alkyl-2-acetylglycerol by treating with phospholipase-C whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d872826258a177a0ae73b131c92f4b
https://pubmed.ncbi.nlm.nih.gov/2938649
https://pubmed.ncbi.nlm.nih.gov/2938649