Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Chaithanya Chelakkot"'
Autor:
Jieun Park, Eun Sol Chang, Ji-Yeon Kim, Chaithanya Chelakkot, Minjung Sung, Ji-Young Song, Kyungsoo Jung, Ji Hye Lee, Jun Young Choi, Na Young Kim, Hyegyeong Lee, Mi-Ran Kang, Mi Jeong Kwon, Young Kee Shin, Yeon Hee Park, Yoon-La Choi
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background Endocrine therapy resistance in hormone receptor-positive/HER2-negative (HR+/HER2−) breast cancer (BC) is a significant clinical challenge that poses several unmet needs in the management of the disease. This study aimed to inve
Externí odkaz:
https://doaj.org/article/2ca855b356e643debe6b235758b1b02b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2606 (2023)
Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ metabolic profile to promote their survival and meet their requirements for energy and macromolecules. This phenomenon, also known as the ‘Warburg effect,’ pro
Externí odkaz:
https://doaj.org/article/0d6b57a5a4534c78812370dc065ead1a
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 75 (2022)
Shedding of cancer cells from the primary site or undetectable bone marrow region into the circulatory system, resulting in clinically overt metastasis or dissemination, is the hallmark of unfavorable invasive cancers. The shed cells remain in circul
Externí odkaz:
https://doaj.org/article/141fd647065f4fbe9655ec9de1488d02
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 8, Pp 1-9 (2018)
Gut health: intestinal barrier function underpins health and disease A better understanding of how the cells that line the inside of the intestines allow nutrients in, while keeping harmful substances and pathogens out could lead to new therapies for
Externí odkaz:
https://doaj.org/article/ec2bf7c57817483e9637780c9919790a
Autor:
Kyoung Song, Nirmal Rajasekaran, Chaithanya Chelakkot, Hun Seok Lee, Seung-Mann Paek, Hobin Yang, Lina Jia, Hee Geon Park, Woo Sung Son, Yu-Jin Kim, Joon-Seok Choi, Hae Min Jeong, Young-Ger Suh, Hwayoung Yun, Young Kee Shin
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1060 (2021)
Aerobic glycolysis in cancer cells, also known as the Warburg effect, is an indispensable hallmark of cancer. This metabolic adaptation of cancer cells makes them remarkably different from normal cells; thus, inhibiting aerobic glycolysis is an attra
Externí odkaz:
https://doaj.org/article/a3cd02d1a0b14c19bfd1763848ecc314
Autor:
Nirmal Rajasekaran, Hun Soon Jung, Soo Hyeon Bae, Chaithanya Chelakkot, Sungyoul Hong, Jong-Sun Choi, Dong-Seok Yim, Yu-Kyoung Oh, Yoon-La Choi, Young Kee Shin
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 735-749 (2017)
Toxicity and resistance remain major challenges for advanced or recurrent cervical cancer therapies, as treatment requires high doses of chemotherapeutic agents. Restoration of TP53 and hypophosphorylated-retinoblastoma (pRB) proteins by human papill
Externí odkaz:
https://doaj.org/article/c2fa6c0b77124668958555288e269051
Autor:
Chaithanya Chelakkot, Jaewang Ghim, Nirmal Rajasekaran, Jong-Sun Choi, Jung-Hwan Kim, Myoung Ho Jang, Young Kee Shin, Pann-Ghill Suh, Sung Ho Ryu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Ulcerative colitis is a multi-factorial disease involving a dysregulated immune response. Disruptions to the intestinal epithelial barrier and translocation of bacteria, resulting in inflammation, are common in colitis. The mechanisms underl
Externí odkaz:
https://doaj.org/article/e627bc7f4f0645b6bc20709220d51531
Autor:
Chaithanya Chelakkot, Jiyeon Ryu, Mi Young Kim, Jin-Soo Kim, Dohyeong Kim, Juhyun Hwang, Sung Hoon Park, Seok Bum Ko, Jeong Won Park, Moon Youn Jung, Ryong Nam Kim, Kyoung Song, Yu Jin Kim, Yoon-La Choi, Hun Seok Lee, Young Kee Shin
Publikováno v:
Micromachines, Vol 11, Iss 6, p 560 (2020)
Here, we validated the clinical utility of our previously developed microfluidic device, GenoCTC, which is based on bottom magnetophoresis, for the isolation of circulating tumor cells (CTCs) from patient whole blood. GenoCTC allowed 90% purity, 77%
Externí odkaz:
https://doaj.org/article/bf6f2d2a4e8c4167b093210be92d5ba4
Autor:
Kyoung Song, Hun Seok Lee, Lina Jia, Chaithanya Chelakkot, Nirmal Rajasekaran, Young Kee Shin
Publikováno v:
Molecules and Cells. 45:413-424
Suppressor of mothers against decapentaplegic homolog (SMAD) 4 is a pluripotent signaling mediator that regulates myriad cellular functions, including cell growth, cell division, angiogenesis, apoptosis, cell invasion, and metastasis, through transfo
Autor:
Jieun Park, Eun Sol Chang, Ji-Yeon Kim, Chaithanya Chelakkot, Minjung Sung, Ji-Young Song, Kyungsoo Jung, Na Young Kim, Hyegyeong Lee, Mi-Ran Kang, Yeon Hee Park, Young Kee Shin, Yoon-La Choi
Publikováno v:
Cancer Research. 83:P5-06
[Background] As the development of endocrine resistance and late recurrences are the major clinical concerns in hormone receptor (HR)-positive/HER2-negative metastatic breast cancer (MBC) patients, biomarkers to predict the occurrence of endocrine re