Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Chaitanya K. Jaladanki"'
Autor:
Therese Yien May Lim, Chaitanya K. Jaladanki, Yi Hao Wong, Thinesshwary Yogarajah, Hao Fan, Justin Jang Hann Chu
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105277- (2024)
Summary: Background: Global cyclical outbreaks of human enterovirus infections has positioned human enterovirus A71 (EV-A71) as a neurotropic virus of clinical importance. However, there remains a scarcity of internationally approved antivirals and v
Externí odkaz:
https://doaj.org/article/727b70da18f644889d05ba8caa63ebc2
Autor:
Ziying Han, Shantoshini Dash, Cari A Sagum, Gordon Ruthel, Chaitanya K Jaladanki, Corbett T Berry, Michael P Schwoerer, Nina M Harty, Bruce D Freedman, Mark T Bedford, Hao Fan, Sachdev S Sidhu, Marius Sudol, Olena Shtanko, Ronald N Harty
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008231 (2020)
Ebola (EBOV) and Marburg (MARV) are members of the Filoviridae family, which continue to emerge and cause sporadic outbreaks of hemorrhagic fever with high mortality rates. Filoviruses utilize their VP40 matrix protein to drive virion assembly and bu
Externí odkaz:
https://doaj.org/article/2b5a06ea5c4348918068392abc239b3c
Autor:
Ariel Shepley-McTaggart, Michael Patrick Schwoerer, Cari A. Sagum, Mark T. Bedford, Chaitanya K. Jaladanki, Hao Fan, Joel Cassel, Ronald N. Harty
Publikováno v:
Viruses, Vol 13, Iss 2, p 288 (2021)
Filoviruses Ebola (EBOV) and Marburg (MARV) are devastating high-priority pathogens capable of causing explosive outbreaks with high human mortality rates. The matrix proteins of EBOV and MARV, as well as eVP40 and mVP40, respectively, are the key vi
Externí odkaz:
https://doaj.org/article/c5e17d7de27d46759d5f3ea2744a9919
Autor:
Hao Fan, Yang He, Haiwei Song, Li Na Zhao, Lit-Hsin Loo, Chaitanya K. Jaladanki, Sebastian Maurer-Stroh
Publikováno v:
Archives of Toxicology
Nuclear receptors (NRs) are key regulators of energy homeostasis, body development, and sexual reproduction. Xenobiotics binding to NRs may disrupt natural hormonal systems and induce undesired adverse effects in the body. However, many chemicals of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b01a6572e02bc2e3a3135069b7aee57
https://doi.org/10.1007/s00204-020-02897-x
https://doi.org/10.1007/s00204-020-02897-x
Autor:
Anuj Gahlawat, Kousar Jahan, Chaitanya K. Jaladanki, Prasad V. Bharatam, Hardeep Sandhu, Gajanan Rathod
Publikováno v:
Drug Metabolism Reviews. 52:366-394
Cytochromes P450 are oxidizing enzymes; a few families of cytochromes P450 are implicated in drug metabolism. These enzymatic reactions involve many processes including (i) prodrug to drug conversion, (ii) easy excretion of drug, (iii) generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2caf0fe3e2fe4a0dd6e68e77b70fa3
https://doi.org/10.1080/03602532.2020.1765792
https://doi.org/10.1080/03602532.2020.1765792
Autor:
Ronald N. Harty, Cari A. Sagum, Michael P. Schwoerer, Mark T. Bedford, Joel Cassel, Hao Fan, Chaitanya K. Jaladanki, Ariel Shepley-McTaggart
Publikováno v:
Viruses, Vol 13, Iss 288, p 288 (2021)
Viruses
Volume 13
Issue 2
Viruses
Volume 13
Issue 2
Filoviruses Ebola (EBOV) and Marburg (MARV) are devastating high-priority pathogens capable of causing explosive outbreaks with high human mortality rates. The matrix proteins of EBOV and MARV, as well as eVP40 and mVP40, respectively, are the key vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0123b7a8524b94521d06f01493ac5a
https://www.mdpi.com/1999-4915/13/2/288
https://www.mdpi.com/1999-4915/13/2/288
Autor:
Gordon Ruthel, Ronald N. Harty, Marius Sudol, Bruce D. Freedman, Mark T. Bedford, Cari A. Sagum, Sachdev S. Sidhu, Chaitanya K. Jaladanki, Hao Fan, Jingjing Liang
Publikováno v:
J Virol
Filoviridae family members Ebola (EBOV) and Marburg (MARV) viruses and Arenaviridae family member Lassa virus (LASV) are emerging pathogens that can cause hemorrhagic fever and high rates of mortality in humans. A better understanding of the interpla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb738a427e8770e3d9bedb66dc51e45
https://doi.org/10.1101/2021.01.26.428359
https://doi.org/10.1101/2021.01.26.428359
Publikováno v:
Chemical research in toxicology 34(6), 1503–1517 (2021). doi:10.1021/acs.chemrestox.0c00450
Drugs containing thiazole and aminothiazole groups are known to generate reactive metabolites (RMs) catalyzed by cytochrome P450s (CYPs). These RMs can covalently modify essential cellular macromolecules and lead to toxicity and induce idiosyncratic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745be6919c7724dfe88b7e8d30d768af
https://hdl.handle.net/2128/28152
https://hdl.handle.net/2128/28152
Publikováno v:
Chemical Research in Toxicology. 30:2060-2073
Hydrazide group (−C(O)–NH–NH2) is considered as a structural alert in the drug discovery process because the biotransformation chemistry of this group leads to the generation of toxic radical intermediates. The most important antitubercular dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e724d2e1634e0304e014eb2196ee3b
https://doi.org/10.1021/acs.chemrestox.7b00129
https://doi.org/10.1021/acs.chemrestox.7b00129
Autor:
Parthasarathi Das, Qazi Naveed Ahmed, Prasad V. Bharatam, Desaboini Nageswar Rao, Gaurav Raina, Sk. Rasheed, Chaitanya K. Jaladanki
Publikováno v:
The Journal of Organic Chemistry. 82:7234-7244
A cobalt-catalyzed proton-coupled electron transfer (PCET) mediated regioselective ortho-specific nitration of aromatic C(sp2)-H bonds using chelation-assisted removable vicinal diamine directing groups was developed. The reaction proceeded under mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa3bd5dc3b303c3e2404c89ea0ddf3e2
https://doi.org/10.1021/acs.joc.7b00808
https://doi.org/10.1021/acs.joc.7b00808