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Haematopoietic development and immunological function in the absence of cathepsin D

Autor: Saftig Paul, Grosvenor Nicholas, Novelli Marco, Uchiyama Yasuo, Tulone Calogero, Chain Benjamin M

Publikováno v: BMC Immunology, Vol 8, Iss 1, p 22 (2007)

Abstract Background Cathepsin D is a well-characterized aspartic protease expressed ubiquitously in lysosomes. Cathepsin D deficiency is associated with a spectrum of pathologies leading ultimately to death. Cathepsin D is expressed at high levels in

Externí odkaz: https://doaj.org/article/6a73cbe0aa1944a683fe0400b2d60a36

Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy

Autor: Joshi, Kroopa ¹, Milighetti, Martina ², Chain, Benjamin M ^{2, 3}

Publikováno v: In Current Opinion in Immunology February 2022 74:1-8

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

Autor: Abbass, Hakam, Abiodun, Aderonke, Alfarih, Mashael, Alldis, Zoe, Altmann, Daniel M, Amin, Oliver E, Andiapen, Mervyn, Artico, Jessica, Augusto, João B, Baca, Georgiana L, Bailey, Sasha NL, Bhuva, Anish N, Boulter, Alex, Bowles, Ruth, Boyton, Rosemary J, Bracken, Olivia V, O'Brien, Ben, Brooks, Tim, Bullock, Natalie, Butler, David K, Captur, Gabriella, Champion, Nicola, Chan, Carmen, Chandran, Aneesh, Collier, David, Couto de Sousa, Jorge, Couto-Parada, Xose, Cutino-Moguel, Teresa, Davies, Rhodri H, Douglas, Brooke, Di Genova, Cecilia, Dieobi-Anene, Keenan, Diniz, Mariana O, Ellis, Anaya, Feehan, Karen, Finlay, Malcolm, Fontana, Marianna, Forooghi, Nasim, Gaier, Celia, Gibbons, Joseph M, Gilroy, Derek, Hamblin, Matt, Harker, Gabrielle, Hewson, Jacqueline, Hickling, Lauren M, Hingorani, Aroon D, Howes, Lee, Hughes, Alun, Hughes, Gemma, Hughes, Rebecca, Itua, Ivie, Jardim, Victor, Lee, Wing-Yiu Jason, Jensen, Melaniepetra, Jones, Jessica, Jones, Meleri, Joy, George, Kapil, Vikas, Kurdi, Hibba, Lambourne, Jonathan, Lin, Kai-Min, Louth, Sarah, Maini, Mala K, Mandadapu, Vineela, Manisty, Charlotte, McKnight, Áine, Menacho, Katia, Mfuko, Celina, Mitchelmore, Oliver, Moon, Christopher, Moon, James C, Munoz Sandoval, Diana, Murray, Sam M, Noursadeghi, Mahdad, Otter, Ashley, Pade, Corinna, Palma, Susana, Parker, Ruth, Patel, Kush, Pawarova, Babita, Petersen, Steffen E, Piniera, Brian, Pieper, Franziska P, Pope, Daniel, Prossora, Maria, Rannigan, Lisa, Rapala, Alicja, Reynolds, Catherine J, Richards, Amy, Robathan, Matthew, Rosenheim, Joshua, Sambile, Genine, Schmidt, Nathalie M, Semper, Amanda, Seraphim, Andreas, Simion, Mihaela, Smit, Angelique, Sugimoto, Michelle, Swadling, Leo, Taylor, Stephen, Temperton, Nigel, Thomas, Stephen, Thornton, George D, Treibel, Thomas A, Tucker, Art, Veerapen, Jessry, Vijayakumar, Mohit, Welch, Sophie, Wodehouse, Theresa, Wynne, Lucinda, Zahedi, Dan, Gupta, Rishi K ^{a, b, *}, Bell, Lucy C ^{b, *}, Guerra-Assuncao, Jose A ^b, Pollara, Gabriele ^b, Whelan, Matthew ^b, McKnight, Aine ⁱ, Chain, Benjamin M ^b

Publikováno v: In The Lancet Microbe October 2021 2(10):e508-e517

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection

Autor: Zhang, Changwang, Zhou, Shi, Groppelli, Elisabetta, Pellegrino, Pierre, Williams, Ian, Borrow, Persephone, Chain, Benjamin M., Jolly, Clare

Publikováno v: PLOS Computational Biology. 2015 Apr 2;11(4):e1004179

HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spread

Externí odkaz: http://arxiv.org/abs/1503.08992