Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Chaim O. Jacob"'
Autor:
Tam D. Quach, Weiqing Huang, Ranjit Sahu, Catherine M.M. Diadhiou, Chirag Raparia, Roshawn Johnson, Tung Ming Leung, Susan Malkiel, Peta Gay Ricketts, Stefania Gallucci, Çagla Tükel, Chaim O. Jacob, Martin L. Lesser, Yong-Rui Zou, Anne Davidson
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
TNF inhibitors are widely used to treat inflammatory diseases; however, 30%–50% of treated patients develop new autoantibodies, and 0.5%–1% develop secondary autoimmune diseases, including lupus. TNF is required for formation of germinal centers
Externí odkaz:
https://doaj.org/article/0bc079a9637640159ce2bb095af989d7
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
In the past two decades, intravital imaging using multiphoton microscopy has provided numerous new visual and mechanistic insights into glomerular biology and disease processes including the function of glomerular endothelial cells (GEnC), podocytes,
Externí odkaz:
https://doaj.org/article/8d78560bd3164c01b22b3c754b62a538
Autor:
Seung Y. Chu, Erik Pong, Christine Bonzon, Ning Yu, Chaim O. Jacob, Samantha A. Chalmers, Chaim Putterman, David E. Szymkowski, William Stohl
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100075- (2021)
Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents a promising target for therapy in autoimmunity. Obexelimab is a non-depleting anti-human CD19 mAb with an Fc region engineered to have high affinity for human Fcγ
Externí odkaz:
https://doaj.org/article/91722979a7e84632bcf95a6a9239fd8d
Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis
Autor:
Hiroyuki Kadoya, Ning Yu, Ina Maria Schiessl, Anne Riquier-Brison, Georgina Gyarmati, Dorinne Desposito, Kengo Kidokoro, Matthew J. Butler, Chaim O. Jacob, János Peti-Peterdi
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
Lupus nephritis (LN) is a major organ complication and cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). There is an unmet medical need for developing more efficient and specific, mechanism-based therapies, which d
Externí odkaz:
https://doaj.org/article/49d4911099a742328b2e305afd6da690
Autor:
Carl D. Langefeld, Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney, Timothy J. Vyse
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hyp
Externí odkaz:
https://doaj.org/article/a68227bc3ba0457486591e4743061bf9
Autor:
Samuel E. Vaughn, Corinne eFoley, Xiaoming eLu, Zubin Hasmukh Patel, Erin E. Zoller, Albert F. Magnusen, Adrienne H. Williams, Julie T. Ziegler, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Adam eAdler, Nan eShen, Swapan eNath, Anne M Stevens, Barry I. Freedman, Betty P. Tsao, Chaim O. Jacob, Diane L Kamen, Elizabeth E Brown, Gary S. Gilkeson, Graciela S. Alarcón, John D. Reveille, Juan-Manuel eAnaya, Judith A. James, Kathy L. Moser, Lindsey A. Criswell, Luis M. Vilá, Marta E. Alarcon-Riquelme, Michelle ePetri, R. Hal Scofield, Robert P. Kimberly, Rosalind eRamsey-Goldman, Young eBinjoo, Jeongim eChoi, Sang-Cheol eBae, Susan A. Boackle, Timothy J. Vyse, Joel M. Guthridge, Bahram eNamjou, Patrick M. Gaffney, Carl D. Langefeld, Kenneth M. Kaufman, Jennifer A Kelly, Isaac TW Harley, John Barker Harley, Leah Claire Kottyan
Publikováno v:
Frontiers in Genetics, Vol 5 (2015)
Genome wide association studies have identified variants in PXK that confer risk for humoral autoimmune diseases, including systemic lupus erythematosus (SLE) or lupus, rheumatoid arthritis and more recently systemic sclerosis. While PXK is involved
Externí odkaz:
https://doaj.org/article/5e75c958d69d4a42bd598e149c6574ec
Autor:
Chaim O. Jacob
Publikováno v:
Rambam Maimonides Medical Journal, Vol 2, Iss 2, p e0044 (2011)
I present a realistic view of what Darwinian evolution is in its current form and what it is not. I argue that the Torah is not a source of scientific knowledge and all attempts to reconcile its plain text with the data of science are an exercise in
Externí odkaz:
https://doaj.org/article/ca9bb9722bb948dc96d94dd14753fe8b
Autor:
Isaac TW Harley, Celi Sun, Adrienne H Williams, Julie T Ziegler, Mary E Comeau, Miranda C Marion, Stuart B Glenn, Adam Adler, Summer G Frank-Pearce, Nan Shen, Jennifer A Kelly, Bahram Namjou-Khales, Michelle Petri, Marta Alarcon-Riquelme, W Joseph McCune, Patrick Gaffney, Kathy Sivils, Jane E Salmon, Michael H Weisman, Jeffrey C Edberg, Elizabeth E Brown, Tammy Utset, Lindsey A Criswell, Chaim O Jacob, Betty Tsao, Timothy J Vyse, Judith A James, Gary S Gilkeson, Diane L Kamen, Courtney Montgomery, Joan T Merrill, Swapan K Nath, Viktoryia Laurynenka, Iouri Chepelev, Valerie Harris-Lewis, R Hal Scofield, Robert P Kimberly, Carl D Langefeld, John B Harley, Kenneth M Kaufman
Publikováno v:
SLE Genetics.
Autor:
Prithvi Raj, Ekta Rai, Ran Song, Shaheen Khan, Benjamin E Wakeland, Kasthuribai Viswanathan, Carlos Arana, Chaoying Liang, Bo Zhang, Igor Dozmorov, Ferdicia Carr-Johnson, Mitja Mitrovic, Graham B Wiley, Jennifer A Kelly, Bernard R Lauwerys, Nancy J Olsen, Chris Cotsapas, Christine K Garcia, Carol A Wise, John B Harley, Swapan K Nath, Judith A James, Chaim O Jacob, Betty P Tsao, Chandrashekhar Pasare, David R Karp, Quan Zhen Li, Patrick M Gaffney, Edward K Wakeland
Publikováno v:
eLife, Vol 5 (2016)
Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset of the variations causing susceptibility to systemic lupus erythematosus (SLE). Two independent disease association signals in the H
Externí odkaz:
https://doaj.org/article/9cb126754a5c4c41a78ee8db59f27c5a
Autor:
Seung Y, Chu, Erik, Pong, Christine, Bonzon, Ning, Yu, Chaim O, Jacob, Samantha A, Chalmers, Chaim, Putterman, David E, Szymkowski, William, Stohl
Publikováno v:
Journal of Translational Autoimmunity
Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents a promising target for therapy in autoimmunity. Obexelimab is a non-depleting anti-human CD19 mAb with an Fc region engineered to have high affinity for human Fcγ