Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Chaim, Gilon"'
Autor:
Alexandra Njegić, Lina Laid, Min Zi, Eleni Maniati, Jun Wang, Alexandru Chelu, Laura Wisniewski, Jenna Hunter, Sukhpal Prehar, Nicholas Stafford, Chaim Gilon, Amnon Hoffman, Michael Weinmüller, Horst Kessler, Elizabeth J. Cartwright, Kairbaan Hodivala-Dilke
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100069- (2024)
Heart failure remains one of the largest clinical burdens globally, with little to no improvement in the development of disease-eradicating therapeutics. Integrin targeting has been used in the treatment of ocular disease and cancer, but little is kn
Externí odkaz:
https://doaj.org/article/a3900e0a7f874b28bce6fe50725d27f9
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 723 (2024)
We describe the design, synthesis, and activity of a potent thiourea-bridged backbone cyclic peptidomimetic known as Clarstatin, comprising a 5-amino acid sequence (Q/D)1-(R/K)2-X3-X4-A5-(Gln/Asp)1-(Arg/Lys)2-AA3-AA4-Ala5-based on a motif called “s
Externí odkaz:
https://doaj.org/article/834edcd997b149c6b94d34589b80d8ed
Autor:
Majdi Saleem Naamneh, Tatjana Momic, Michal Klazas, Julius Grosche, Johannes A. Eble, Cezary Marcinkiewicz, Netaly Khazanov, Hanoch Senderowitz, Amnon Hoffman, Chaim Gilon, Jehoshua Katzhendler, Philip Lazarovici
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 549 (2024)
To develop peptide drugs targeting integrin receptors, synthetic peptide ligands endowed with well-defined selective binding motifs are necessary. The snake venom KTS-containing disintegrins, which selectively block collagen α1β1 integrin, were use
Externí odkaz:
https://doaj.org/article/a2507c50643f46cfb8943819957681cd
Autor:
Mladena Glavaš, Agata Gitlin-Domagalska, Natalia Ptaszyńska, Dominika Starego, Sylwia Freza, Dawid Dębowski, Aleksandra Helbik-Maciejewska, Anna Łęgowska, Chaim Gilon, Krzysztof Rolka
Publikováno v:
Molecules, Vol 28, Iss 23, p 7780 (2023)
Arginine, due to the guanidine moiety, increases peptides’ hydrophilicity and enables interactions with charged molecules, but at the same time, its presence in a peptide chain might reduce its permeability through biological membranes. This might
Externí odkaz:
https://doaj.org/article/989f5ba2e7a34153ac3dd01b70a7256f
Autor:
Chaim Gilon, Michal Klazas, Adi Lahiani, Adi Schumacher-Klinger, Shira Merzbach, Johnny N. Naoum, Haim Ovadia, Limor Rubin, Susan Cornell-Kennon, Erik M. Schaefer, Jehoshua Katzhendler, Cezary Marcinkiewicz, Amnon Hoffman, Philip Lazarovici
Publikováno v:
JACS Au, Vol 1, Iss 12, Pp 2361-2376 (2021)
Externí odkaz:
https://doaj.org/article/d3a290a521dd414dba56442f22ad6166
Autor:
Gerard Marx, Chaim Gilon
Publikováno v:
Journal of Integrative Neuroscience, Vol 18, Iss 2, Pp 181-185 (2019)
In this paper, we address the enigma of the memory engram, the physical trace of memory in terms of its composition, processes, and location. A neurochemical approach assumes that neural processes hinge on the same terms used to describe the biochemi
Externí odkaz:
https://doaj.org/article/652f15424a774c1b94d6120d29611edd
Autor:
Alaa Talhami, Avi Swed, Shmuel Hess, Oded Ovadia, Sarit Greenberg, Adi Schumacher-Klinger, David Rosenthal, Deborah E. Shalev, Mattan Hurevich, Philip Lazarovici, Amnon Hoffman, Chaim Gilon
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like morphine are highly addictive. We present a general approach aimed to use backbone-cyclizat
Externí odkaz:
https://doaj.org/article/214c0a356de24363ad9340767112adf5
Autor:
Kiran Kumar Tadi, Israel Alshanski, Evgeniy Mervinetsky, Gerard Marx, Panayiota Petrou, Karussis M. Dimitrios, Chaim Gilon, Mattan Hurevich, Shlomo Yitzchaik
Publikováno v:
ACS Omega, Vol 2, Iss 12, Pp 8770-8778 (2017)
Externí odkaz:
https://doaj.org/article/d85b8da00c64402c92a5c67bd0935a71
Autor:
Gerard Marx, Chaim Gilon
Publikováno v:
AIMS Medical Science, Vol 4, Iss 3, Pp 241-260 (2017)
The link of memory to intelligence is incontestable, though the development of electronic artifacts with memory has confounded cognitive and computer scientists’ conception of memory and its relevance to “intelligence”. We propose two categorie
Externí odkaz:
https://doaj.org/article/63c983aa01fe403695d44a75328c6644
Autor:
Johnny N. Naoum, Koushik Chandra, Dorit Shemesh, R. Benny Gerber, Chaim Gilon, Mattan Hurevich
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 806-816 (2017)
Several multistep strategies were developed to ensure single methylation of amines on solid support. These strategies rely on the introduction of the o-NBS protecting/activating group as a key step. We found that the state-of-the-art strategies fail
Externí odkaz:
https://doaj.org/article/9022c090c61b4f9eb731428ac76ea552