Výsledky vyhledávání - "Chai Ping Lee"

2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1

Autor: Chang Kai Soh, Kay Lin Goh, Meredith Williams, Kantharaj Ethirajulu, Haishan Wang, Zahid Bonday, Jeanette Marjorie Wood, Miah Kiat Goh, Kee Chuan Goh, Brian Dymock, Anders Poulsen, Stéphanie Blanchard, Mohammed Khalid Pasha, Chai Ping Lee

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:2880-2884

A series of 2-anilino substituted 4-aryl-8H-purines were prepared as potent inhibitors of PDK1, a serine-threonine kinase thought to play a role in the PI3K/Akt signaling pathway, a key mediator of cancer cell growth, survival and tumorigenesis. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e326a1e8754536639d26a7d08fc874
https://doi.org/10.1016/j.bmcl.2012.02.058

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Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis

Autor: Ramesh Jayaraman, Anders Poulsen, Angeline C.-H. Lee, Jeanette Marjorie Wood, Haishan Wang, Kantharaj Ethirajulu, Stefan Hart, Babita Madan, Evelyn Tan, Chai Ping Lee, Eric T. Sun, Anthony D. William, Dizhong Chen, Harish Kumar Mysore Nagaraj, Mohammad Khalid Pasha, Brian Dymock, Kee Chuan Goh

Publikováno v: Journal of Medicinal Chemistry. 55:2623-2640

Herein, we describe the synthesis and SAR of a series of small molecule macrocycles that selectively inhibit JAK2 kinase within the JAK family and FLT3 kinase. Following a multiparameter optimization of a key aryl ring of the previously described SB1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fde29aeb4e110b4ffa85de784e94e504
https://doi.org/10.1021/jm201454n

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Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer

Autor: Stéphanie Blanchard, Mohammed Khalid Pasha, Harish Kumar Mysore Nagaraj, Eric T. Sun, Changyong Hu, Anthony D. William, Chai Ping Lee, Anders Poulsen, Ramesh Jayaraman, Meredith Williams, Jeanette Marjorie Wood, Kee Chuan Goh, Kantharaj Ethirajulu, Angeline C.-H. Lee, Haishan Wang, Ee Ling Teo, Brian Dymock

Publikováno v: Journal of Medicinal Chemistry. 55:169-196

Herein, we describe the design, synthesis, and SAR of a series of unique small molecule macrocycles that show spectrum selective kinase inhibition of CDKs, JAK2, and FLT3. The most promising leads were assessed in vitro for their inhibition of cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e3eb11f4d4fda7836ce98938e6c981
https://doi.org/10.1021/jm201112g

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Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritis

Autor: Anthony D, William, Angeline C-H, Lee, Anders, Poulsen, Kee Chuan, Goh, Babita, Madan, Stefan, Hart, Evelyn, Tan, Haishan, Wang, Harish, Nagaraj, Dizhong, Chen, Chai Ping, Lee, Eric T, Sun, Ramesh, Jayaraman, Mohammad Khalid, Pasha, Kantharaj, Ethirajulu, Jeanette M, Wood, Brian W, Dymock

Publikováno v: Journal of medicinal chemistry. 55(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3107f6654511b9483942d1145c2d6619
https://pubmed.ncbi.nlm.nih.gov/22339472

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