Efficacy of COVID-19 vaccines in immunocompromised patients: A systematic review and meta-analysis

Autor: Chai Lya, Lee M, Chong Boon Teo, Muthiah, Wong Sy, Lee Aryb, Lee Sc, Soon Yy, Tan Bkj, Tay Sh, Yiong Huak Chan, Sundar R

ObjectiveTo compare the efficacy of COVID 19 vaccines between those with immunocompromised medical conditions and those who are immunocompetentDesignSystematic review and meta-analysisData sourcesPubMed, EMBASE, CENTRAL, CORD-19 and WHO COVID-19 rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7a1654f83ff83fcc46e3791ffa2eca2
https://doi.org/10.1101/2021.09.28.21264126

Severe invasive infections linked to IRAK2 immune variants.

Autor: Amali AA; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore., Paramasivam K; Mechanobiology Institute, National University of Singapore, Singapore., Ravikumar S; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore., Tan Z; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore., Loong SSE; Cardiovascular Metabolic Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chong KHC; NTU Institute of Structural Biology, Nanyang Technological University, Singapore., Ang A; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore., Zhu J; Mechanobiology Institute, National University of Singapore, Singapore., Rao SS; National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore., Chai LYA; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: chailouis@hotmail.com.

Publikováno v: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Nov; Vol. 148, pp. 107245. Date of Electronic Publication: 2024 Sep 17.

COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection.

Autor: Mahyuddin AP; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Swa HLF; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore., Weng R; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore., Zhang J; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore., Dhanaraj JP; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore., Sesurajan BP; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Rauff M; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore., Dashraath P; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore., Kanneganti A; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore., Lee R; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore., Wang LF; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; The Programme for Research in Epidemic Preparedness and Response (PREPARE), National Centre for Infectious Diseases, Singapore, Singapore., Young BE; The Programme for Research in Epidemic Preparedness and Response (PREPARE), National Centre for Infectious Diseases, Singapore, Singapore; National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tambyah PA; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore., Lye DC; The Programme for Research in Epidemic Preparedness and Response (PREPARE), National Centre for Infectious Diseases, Singapore, Singapore; National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chai LYA; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore., Yee S; Innovation and Enterprise, Agency for Science, Technology and Research, Connexis North Tower, Singapore, Singapore., Choolani M; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore., Mattar CNZ; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore. Electronic address: citramattar@nus.edu.sg.

Publikováno v: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Sep; Vol. 146, pp. 107121. Date of Electronic Publication: 2024 May 31.

Adding Hyponatremia to the "Rule-of-6" Prediction Tool Improves Performance in Identifying Hospitalised Patients with COVID-19 at Risk of Adverse Clinical Outcomes.

Autor: Sim MY; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore 119228, Singapore., Ngiam JN; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore 119228, Singapore., Koh MCY; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore 119228, Singapore., Goh W; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore 119228, Singapore., Chhabra S; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore 119228, Singapore., Chew NWS; Department of Cardiology, National University Heart Centre Singapore, Singapore 119074, Singapore., Chai LYA; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore 119228, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Tambyah PA; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore 119228, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Sia CH; Department of Cardiology, National University Heart Centre Singapore, Singapore 119074, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

Publikováno v: Pathogens (Basel, Switzerland) [Pathogens] 2024 Aug 16; Vol. 13 (8). Date of Electronic Publication: 2024 Aug 16.

Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity.

Autor: Lin QXX; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Rajagopalan D; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Gamage AM; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore., Tan LM; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Venkatesh PN; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Chan WOY; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore., Kumar D; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore., Agrawal R; Department of Microbiology and Cell Biology, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, 560012, India., Chen Y; A*STAR Infectious Diseases Labs (A*STAR ID Labs), A*STAR, Singapore, 138648, Singapore., Fong SW; A*STAR Infectious Diseases Labs (A*STAR ID Labs), A*STAR, Singapore, 138648, Singapore., Singh A; Department of Microbiology and Cell Biology, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, 560012, India., Sun LJ; Alexandra Hospital, Singapore, 159964, Singapore., Tan SY; Changi General Hospital, Singapore, 529889, Singapore., Chai LYA; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, 119228, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Somani J; Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, 119228, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Lee B; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore.; A*STAR Infectious Diseases Labs (A*STAR ID Labs), A*STAR, Singapore, 138648, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921, Singapore., Renia L; A*STAR Infectious Diseases Labs (A*STAR ID Labs), A*STAR, Singapore, 138648, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921, Singapore., Ng LFP; A*STAR Infectious Diseases Labs (A*STAR ID Labs), A*STAR, Singapore, 138648, Singapore., Ramanathan K; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; National University Hospital, Singapore, 119074, Singapore., Wang LF; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore.; SingHealth Duke-NUS Global Health Institute, Singapore, 168753, Singapore., Young B; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921, Singapore.; National Centre for Infectious diseases, Singapore, 308442, Singapore.; Tan Tock Seng Hospital, Singapore, 308433, Singapore., Lye D; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921, Singapore.; National Centre for Infectious diseases, Singapore, 308442, Singapore.; Tan Tock Seng Hospital, Singapore, 308433, Singapore., Singhal A; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore. amit_singhal@idlabs.a-star.edu.sg.; A*STAR Infectious Diseases Labs (A*STAR ID Labs), A*STAR, Singapore, 138648, Singapore. amit_singhal@idlabs.a-star.edu.sg., Prabhakar S; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore. prabhakars@gis.a-star.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2024 Jan 18; Vol. 15 (1), pp. 567. Date of Electronic Publication: 2024 Jan 18.