Preparation and biological evaluation of new antimicrotubule agents: Modification of the imidazolidin-2-one moiety of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates

Autor: Sébastien Fortin, Mathieu Gagné-Boulet, Atziri Corin Chavez Alvarez, Chahrazed Bouzriba

Publikováno v: Chemical biologydrug designREFERENCES. 99(2)

We prepared and biologically evaluated 32 novel molecules named phenyl 4-(dioxoimidazolidin-1-yl)benzenesulfonates (PID-SOs) and ethyl 2-(3-(4-(phenoxysulfonyl)phenyl)ureido)acetates (EPA-SOs). The antiproliferative activity of PID-SOs and EPA-SOs wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c451196151beaa5b2292a59007aab6d7
https://pubmed.ncbi.nlm.nih.gov/34623027

Phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonates and phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonamides as new antimicrotubule agents targeting the colchicine-binding site

Autor: Chahrazed Bouzriba, Mathieu Gagné-Boulet, Sébastien Fortin, Atziri Corin Chavez Alvarez

Publikováno v: European journal of medicinal chemistry. 213

We recently designed and prepared new families of potent antimicrotubule agents designated as N-phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB–SOs) and phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides (PIB–SAs). Our previous structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e36fcb9151a814661e289d2246e82
https://pubmed.ncbi.nlm.nih.gov/33472119

Preparation, characterisation and biological evaluation of new N-phenyl amidobenzenesulfonates and N-phenyl ureidobenzenesulfonates inducing DNA double-strand breaks. Part 3. Modulation of ring A

Autor: Chahrazed Bouzriba, Marvin Godard, Sébastien Fortin, Mathieu Gagné-Boulet

Publikováno v: European Journal of Medicinal Chemistry. 155:681-694

N-Phenyl ureidobenzenesulfonates (PUB-SOs) are a new class of anticancer agents blocking the cell cycle progression in S-phase, inducing replicative stress and DNA double-strand breaks (DSBs). In this study, we evaluate the effect of modifying the na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9458ea400c873c6f303ccd35e40ea65a
https://doi.org/10.1016/j.ejmech.2018.06.030

Abstract 286: Conception and preparation of new potent antimicrotubule agents

Autor: Chahrazed Bouzriba, Mathieu Gagné-Boulet, Sébastien Fortin, Atziri Corin Chavez Alvarez

Publikováno v: Cancer Research. 81:286-286

Cancer is still to this day one of the first causes of death in industrialized countries. Despite great progress made so far, there is still no treatment completely efficient and without toxicity. Therefore, the development of new anticancer drugs is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ec1e148890fe53ee4520b3f965052e2
https://doi.org/10.1158/1538-7445.am2021-286

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside–LecA Interactions

Autor: Danny Lainé, Emilie Gillon, Chahrazed Bouzriba, Elena Shanina, Vincent Denavit, Denis Giguère, Christoph Rademacher, Sébastien Fortin, Anne Imberty

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2019, 25 (17), pp.4478-4490. ⟨10.1002/chem.201806197⟩
Chemistry-A European Journal, 2019, 25 (17), pp.4478-4490. ⟨10.1002/chem.201806197⟩

The replacement of hydroxyl groups by fluorine atoms on hexopyranoside scaffolds may allow access to invaluable tools for studying various biochemical processes. As part of ongoing activities toward the preparation of fluorinated carbohydrates, a sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba3bbf6b9fcd98120e875dd1dc1af50
https://hal.archives-ouvertes.fr/hal-02104563