Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis

Autor: Astrid De Roover, Ana Escribano Núñez, Frederique M.F. Cornelis, Chahrazad Cherifi, Leire Casas-Fraile, An Sermon, Frederic Cailotto, Rik J. Lories, Silvia Monteagudo

Publikováno v: JCI Insight, Vol 6, Iss 24 (2021)

Osteoarthritis is the most prevalent joint disease worldwide, and it is a leading source of pain and disability. To date, this disease lacks curative treatment, as underlying molecular mechanisms remain largely unknown. The histone methyltransferase

Externí odkaz: https://doaj.org/article/243f9866ad414a8389f23a86d7ec7000

Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis

Autor: Reem Assi, Chahrazad Cherifi, Frederique M.F. Cornelis, Qiongfei Zhou, Lies Storms, Sofia Pazmino, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt, Rik J. Lories, Silvia Monteagudo

Publikováno v: Annals of the Rheumatic Diseases. :ard-2022

ObjectivesIn osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone methyltransferases and demethylases. Here, we aimed to ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ba634ad2eecc9828bd14464deeb13ae
https://doi.org/10.1136/ard-2022-223789

Articular cartilage hypoxia is a potential target for OA therapy

Autor: An Sermon, Ana Escribano Núñez, Rik Lories, Astrid de Roover, F.M. Cornelis, Frédéric Cailotto, Silvia Monteagudo, Leire Casas-Fraile, Chahrazad Cherifi

Publikováno v: JCI Insight

Osteoarthritis is the most prevalent joint disease worldwide and a leading source of pain and disability. To date, this disease lacks curative treatment as underlying molecular mechanisms remain largely unknown. The histone methyltransferase DOT1L pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f846150463a9e718c02f9957be319357
https://pubmed.ncbi.nlm.nih.gov/34727094

Promising targets for therapy of osteoarthritis: a review on the Wnt and TGF-beta signalling pathways

Autor: Chahrazad Cherifi, Rik Lories, Silvia Monteagudo

Publikováno v: Therapeutic Advances in Musculoskeletal Disease
Therapeutic Advances in Musculoskeletal Disease, Vol 13 (2021)

Osteoarthritis (OA) is the most common chronic joint disorder worldwide, with a high personal burden for the patients and an important socio-economic impact. Current therapies are largely limited to pain management and rehabilitation and exercise str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa2977eac5845aa387d093a6beac1da
https://lirias.kuleuven.be/handle/123456789/675878

A Graftable Quaternary Ammonium Biocidal Polymer Reduces Biofilm Formation and Ensures Biocompatibility of Medical Devices

Autor: Charles Court, Anne-Claude Crémieux, Chahrazad Cherifi, Martine Cohen-Solal, Narjes Hafsia, Claire Valotteau, Vincent Humblot, Azzam Saleh-Mghir, Houssam Bouloussa

Publikováno v: Advanced Materials Interfaces
Advanced Materials Interfaces, Wiley, 2021, pp.2001516. ⟨10.1002/admi.202001516⟩
Advanced Materials Interfaces, 2021, pp.2001516. ⟨10.1002/admi.202001516⟩

International audience; A quaternized polyvinylpyridine (Q‐PVP) polymer methanolic solution synthesized in a single step is used to covalently graft titanium surfaces. Q‐PVP is quaternized with varying N+/N ratios. 1 cm2 pure titanium plates are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ff156920cd6a5ab28461f157f1fb6f
https://hal.sorbonne-universite.fr/hal-03155802/document