The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase.

Autor: Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Yang K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Abou Farraj R; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada., Saed CT; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Chan JSF; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Chahade JJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Lee C; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Velázquez-Martínez CA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada., Crawford PA; Division of Molecular Medicine, Department of Medicine, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN., Glover JNM; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada., Al Batran R; Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

Publikováno v: Diabetes [Diabetes] 2023 Jan 01; Vol. 72 (1), pp. 126-134.

The GLP-1 Receptor Agonist Liraglutide Increases Myocardial Glucose Oxidation Rates via Indirect Mechanisms and Mitigates Experimental Diabetic Cardiomyopathy.

Autor: Almutairi M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Young A; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada., Gill R; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada., Aburasayn H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Chahade JJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Gandhi M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada., Mailloux RJ; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada. Electronic address: jussher@ualberta.ca.

Publikováno v: The Canadian journal of cardiology [Can J Cardiol] 2021 Jan; Vol. 37 (1), pp. 140-150. Date of Electronic Publication: 2020 Mar 08.

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation.

Autor: Al Batran R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Capozzi ME; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Chahade JJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Saleme B; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Tabatabaei-Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada., Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Niu J; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Almutairi M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Byrne NJ; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Masson G; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Kim R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Mulvihill EE; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Garneau L; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada; Institut du Savoir Montfort, Ottawa, ON, Canada., Masters AR; Indiana University School of Medicine, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA., Desta Z; Department of Medicine, Division of Clinical Pharmacology, Indianapolis, IN, USA., Velázquez-Martínez CA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada., Aguer C; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada; Institut du Savoir Montfort, Ottawa, ON, Canada; School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada., Crawford PA; Division of Molecular Medicine, Department of Medicine, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Sutendra G; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Campbell JE; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Dyck JRB; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada. Electronic address: jussher@ualberta.ca.

Publikováno v: Cell metabolism [Cell Metab] 2020 May 05; Vol. 31 (5), pp. 909-919.e8. Date of Electronic Publication: 2020 Apr 09.