GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels

Autor: Desiré Casares-Marfil, Martin Kerick, Eduardo Andrés-León, Pau Bosch-Nicolau, Israel Molina, Chagas Genetics CYTED Network, Javier Martin, Marialbert Acosta-Herrera

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)

A recent genome-wide association study (GWAS) identified a locus in chromosome 11 associated with the chronic cardiac form of Chagas disease. Here we aimed to elucidate the potential functional mechanism underlying this genetic association by analyzi

Externí odkaz: https://doaj.org/article/cf1f6ec80ef34ecc938e4827580116eb

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Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations

Autor: Strauss, Mariana, Acosta Herrera, Marialbert, Alcaraz, Alexia, Casares Marfil, Desiré, Bosch Nicolau, Pau, Lo Presti, Maria Silvina, Molina, Israel, González, Clara Isabel, Martín, Javier, Chagas Genetics CYTED Network

Publikováno v: PLoS Neglected Tropical Diseases
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientia
PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007859 (2019)

Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2278ff0620f8b74b231d4507497daaf
https://pubmed.ncbi.nlm.nih.gov/31751351