Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chafiq Moummi"'
Autor:
Dai-Chang Yang, G. W. Gullikson, Daniel L. Flynn, Daniel P. Becker, Clara I. Villamil, Roger Nosal, Chafiq Moummi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2149-2154
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b42abbb49f0bda55dc9bbc18197fba
https://doi.org/10.1016/s0960-894x(97)00408-3
https://doi.org/10.1016/s0960-894x(97)00408-3
Autor:
Dai-Chang Yang, Roger Nosal, Daniel L. Flynn, Clara I. Villamil, Chafiq Moummi, G. W. Gullikson, Daniel P. Becker
Publikováno v:
ChemInform. 29
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60106a1804efbed52b309ff774b120a9
https://doi.org/10.1002/chin.199801172
https://doi.org/10.1002/chin.199801172
Autor:
Chafiq Moummi, Dai-Chang Yang, Daniel L. Flynn, Roger Nosal, Daniel P. Becker, G. W. Gullikson, Dale P. Spangler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1613-1618
New aza(nor)adamantanes 1A , 1B , and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8ca2120c6861af925b4314701bf4e8
https://doi.org/10.1016/s0960-894x(00)80441-2
https://doi.org/10.1016/s0960-894x(00)80441-2
Autor:
Daniel L. Flynn, Chafiq Moummi, Dai-Chang Yang, Daniel P. Becker, G. W. Gullikson, Clara I. Villamil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1251-1256
A new series of cholecystokinin (CCK) antagonists are described which utilizes a new 1,3,4-trisubstituted pyrrolidinone as a scaffold for appending specific amino acid R group mimics (Figure 1). Compound 1A and 1E (SC-50998) exhibit potent nanomolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf05097a14e72e4db52a818dfe925918
https://doi.org/10.1016/s0960-894x(00)80224-3
https://doi.org/10.1016/s0960-894x(00)80224-3
Publikováno v:
European Journal of Pharmacology. 216:47-52
Changes in mechanical events and intracellular levels of cAMP induced by the activation of the 5-HT4 receptor were investigated in the rat esophagus tunica muscularis mucosae preparation. Serotonin (5-HT) and 5 methoxytryptamine (5-MOT; 5-HT4 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3acd529624afe4f27cca7570f8bc63
https://doi.org/10.1016/0014-2999(92)90207-k
https://doi.org/10.1016/0014-2999(92)90207-k
Autor:
Daniel L. Flynn, Gary W. Gullikson, Roger Nosal, Dai C. Yang, Daniel Lamar Zabrowski, Daniel P. Becker, Chafiq Moummi, Clara I. Villamil
Publikováno v:
Journal of Medicinal Chemistry. 35:1486-1489
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3639941cbf94a1833d4761d48f2eeaf0
https://doi.org/10.1021/jm00086a019
https://doi.org/10.1021/jm00086a019
Autor:
Mark Woodford, Chafiq Moummi
Publikováno v:
Drug Development Research. 25:325-329
We have developed a state-of-the-art computerized system to measure the cell length (contraction/relaxation) of single isolated gastrointestinal smooth muscle cells in response to different drugs. The system is composed of a microscope to which a vid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eeb5ffef274d96dafa720a24d9f55c1
https://doi.org/10.1002/ddr.430250407
https://doi.org/10.1002/ddr.430250407
Publikováno v:
Drug Development Research. 27:137-145
The regulation of inhibition of carbachol-induced contraction by β-adrenoceptors of rabbit gastric antrum has been investigated. A functional assay using isolated smooth muscle cells (ISMC) was used to study the effect of β-adrenergic agonists and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edd53af1fe397d8b229ba88a84fa5719
https://doi.org/10.1002/ddr.430270206
https://doi.org/10.1002/ddr.430270206
Autor:
Chafiq Moummi
Publikováno v:
Drug Development Research. 27:53-60
The present study was performed to examine the mechanism of action of neurokinin A (NKA) on guinea pig gallbaldder smooth muscle. Muscle strips were prepared and mounted in 10 mL tissue bath containing Krebs' solution under 1 g tension. NKA induced a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2590f4db9fa8a66efa46d1a5d0de331
https://doi.org/10.1002/ddr.430270106
https://doi.org/10.1002/ddr.430270106
Autor:
Roger Nosal, Alan E. Moormann, Richard F. Loeffler, Daniel L. Flynn, Gary W. Gullikson, Clara I. Villamil, Daniel P. Becker, Chafiq Moummi, Dai-C Yang
Publikováno v:
Journal of medicinal chemistry. 49(3)
A series of pyrrolizidine esters, amides, and ureas was prepared and tested for 5-HT(4) and 5-HT(3) receptor binding, 5-HT(4) receptor agonism in the rat tunica muscularis mucosae (TMM) assay, and for 5-HT(3) receptor-mediated functional antagonism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96245f0a4c5942c7ba475cf5b51ceebe
https://pubmed.ncbi.nlm.nih.gov/16451077
https://pubmed.ncbi.nlm.nih.gov/16451077