Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Chaffiol, A."'
Autor:
Antoine Chaffiol, Matthieu Provansal, Corentin Joffrois, Kévin Blaize, Guillaume Labernede, Ruben Goulet, Emma Burban, Elena Brazhnikova, Jens Duebel, Pierre Pouget, José Alain Sahel, Serge Picaud, Fabrice Arcizet, Gregory Gauvain
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 1-10 (2022)
Over the last 15 years, optogenetics has changed fundamental research in neuroscience and is now reaching toward therapeutic applications. Vision restoration strategies using optogenetics are now at the forefront of these new clinical opportunities.
Externí odkaz:
https://doaj.org/article/3539475107dc44d68426b97714ec967c
Autor:
Tabatha R. Simmons, Tatyana A. Vetter, Nianyuan Huang, Adeline Vulin-Chaffiol, Nicolas Wein, Kevin M. Flanigan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 325-340 (2021)
Duchenne muscular dystrophy (DMD) is an X-linked progressive disease characterized by loss of dystrophin protein that typically results from truncating mutations in the DMD gene. Current exon-skipping therapies have sought to treat deletion mutations
Externí odkaz:
https://doaj.org/article/6912488c4ecd404facb01ca8c3e269ec
Autor:
M. Provansal, G. Labernède, C. Joffrois, A. Rizkallah, R. Goulet, M. Valet, W. Deschamps, U. Ferrari, A. Chaffiol, D. Dalkara, J. A. Sahel, M. Tanter, S. Picaud, G. Gauvain, F. Arcizet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Optogenetics has revolutionized neurosciences by allowing fine control of neuronal activity. An important aspect for this control is assessing the activation and/or adjusting the stimulation, which requires imaging the entire volume of optog
Externí odkaz:
https://doaj.org/article/1dd37e80ffb447ca9a7dfd8e7970b325
Autor:
Gregory Gauvain, Himanshu Akolkar, Antoine Chaffiol, Fabrice Arcizet, Mina A. Khoei, Mélissa Desrosiers, Céline Jaillard, Romain Caplette, Olivier Marre, Stéphane Bertin, Claire-Maelle Fovet, Joanna Demilly, Valérie Forster, Elena Brazhnikova, Philippe Hantraye, Pierre Pouget, Anne Douar, Didier Pruneau, Joël Chavas, José-Alain Sahel, Deniz Dalkara, Jens Duebel, Ryad Benosman, Serge Picaud
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable con
Externí odkaz:
https://doaj.org/article/0b4ca90d06f64da69afaff7c49d68f90
Autor:
Tournier, Marie, Neumann, Anke, Pambrun, Elodie, Weill, Alain, Chaffiol, Jean-Philippe, Alla, François, Bégaud, Bernard, Maura, Géric, Verdoux, Hélène
Publikováno v:
In Journal of Affective Disorders 1 October 2019 257:412-420
Autor:
Pouzat, Christophe, Chaffiol, Antoine
After an elementary derivation of the "time transformation", mapping a counting process onto a homogeneous Poisson process with rate one, a brief review of Ogata's goodness of fit tests is presented and a new test, the "Wiener process test", is propo
Externí odkaz:
http://arxiv.org/abs/0909.2785
Autor:
Marcela Garita-Hernandez, Maruša Lampič, Antoine Chaffiol, Laure Guibbal, Fiona Routet, Tiago Santos-Ferreira, Sylvia Gasparini, Oliver Borsch, Giuliana Gagliardi, Sacha Reichman, Serge Picaud, José-Alain Sahel, Olivier Goureau, Marius Ader, Deniz Dalkara, Jens Duebel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
A challenge in cell therapy for photoreceptor degeneration is inducing the grafted cells to grow and maintain light sensitive outer segments. Here, the authors use optogenetics to circumvent this problem and restore visual function in blind mice.
Externí odkaz:
https://doaj.org/article/732d87294a534f1ab4fe044f1dcd7507
Autor:
Marcela Garita-Hernandez, Antoine Chaffiol, Laure Guibbal, Fiona Routet, Hanen Khabou, Luisa Riancho, Lyes Toualbi, Serge Picaud, José-Alain Sahel, Olivier Goureau, Jens Duebel, Deniz Dalkara
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Human-induced pluripotent stem cell (hiPSC) derived organoids have become increasingly used systems allowing 3D-modeling of human organ development, and disease. They are also a reliable source of cells for transplantation in cell therapy and an exce
Externí odkaz:
https://doaj.org/article/d52cba0458fb442b986f0c8aa3494476
Autor:
Alice Louail, Martijn C. Sierksma, Antoine Chaffiol, Sarah Baudet, Ahlem Assali, Sandrine Couvet, Melissa Nedjam, Fiona Roche, Yvrick Zagar, Jens Duebel, Xavier Nicol
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108220- (2020)
Summary: Axonal arbors in many neuronal networks are exuberant early during development and become refined by activity-dependent competitive mechanisms. Theoretical work proposed non-competitive interactions between co-active axons to co-stabilize th
Externí odkaz:
https://doaj.org/article/10e1a87e82a343e2aad89c4baa8a811b
Autor:
Oriane Rabesandratana, Antoine Chaffiol, Antoine Mialot, Amélie Slembrouck-Brec, Corentin Joffrois, Céline Nanteau, Amélie Rodrigues, Giuliana Gagliardi, Sacha Reichman, José-Alain Sahel, Alain Chédotal, Jens Duebel, Olivier Goureau, Gael Orieux
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Optic neuropathies are a major cause of visual impairment due to retinal ganglion cell (RGC) degeneration. Human induced-pluripotent stem cells (iPSCs) represent a powerful tool for studying both human RGC development and RGC-related pathological mec
Externí odkaz:
https://doaj.org/article/1110a7efc5424ef18f2b689f99244a88