Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chae Young Cha"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0124970 (2015)
Mathematical cell models are effective tools to understand cellular physiological functions precisely. For detailed analysis of model dynamics in order to investigate how much each component affects cellular behaviour, mathematical approaches are ess
Externí odkaz:
https://doaj.org/article/5694129cc66d454b8c3e026d2c8274a2
Autor:
Chae Young Cha, Sooyoung Cho
Publikováno v:
The Korean Journal of Advertising and Public Relations. 24:439-483
Autor:
Akinori Noma, Yukiko Himeno, Chae Young Cha, Keiichi Asakura, Trevor Powell, Akira Amano, Hiraku Memida
Publikováno v:
Biophysical Journal. 109(2):415-427
Cardiac Ca(2+)-induced Ca(2+) release (CICR) occurs by a regenerative activation of ryanodine receptors (RyRs) within each Ca(2+)-releasing unit, triggered by the activation of L-type Ca(2+) channels (LCCs). CICR is then terminated, most probably by
Autor:
Akinori Noma, H. Memida, K. Asakura, Trevor Powell, H. Yamaoka, Y. Horikawa, Chae Young Cha, Akira Amano
Publikováno v:
Progress in Biophysics and Molecular Biology. 116:11-24
It has long been suggested that the Ca(2+)-mechanisms are largely involved in generating the early afterdepolarization (EAD) as well as the delayed afterdepolarization (DAD). This view was examined in a quantitative manner by applying the lead potent
Autor:
Makoto Shigeto, Manuela Zaccolo, Reshma Ramracheya, Antony Galione, William Sones, Thomas Reinbothe, Benoit Hastoy, Rudi Vennekens, Elisa Vergari, Cathryn Weston, Graham Ladds, Viacheslav O. Nikolaev, Chae Young Cha, Masashi Katsura, Nils J.G. Rorsman, Andrei I. Tarasov, Patrik Rorsman, Paul Johnson, Julia Gorelik, Koenraad Philippaert, Margarita V. Chibalina, Albert Salehi, Kohei Kaku
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce9c8d589f091227aa5ae7d0286bf35
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 95(4)
Glucagon-like peptide-1 (GLP-1) is an endogenous glucose-lowering hormone and GLP-1 receptor agonists are currently being used as antidiabetic drugs clinically. The canonical signalling pathway (including cAMP, Epac2, protein kinase A (PKA) and KATP
Publikováno v:
Progress in Biophysics and Molecular Biology. 107:265-273
Bursts of repetitive action potentials are closely related to the regulation of glucose-induced insulin secretion in pancreatic β cells. Mathematical studies with simple β-cell models have established the central principle that the burst-interburst
Publikováno v:
The Journal of General Physiology
In our companion paper, the physiological functions of pancreatic β cells were analyzed with a new β-cell model by time-based integration of a set of differential equations that describe individual reaction steps or functional components based on e
Autor:
Chae Young Cha, Hiroyasu Satoh, Hiroshi Matsuura, Akinori Noma, Futoshi Toyoda, Yukiko Himeno, Akira Amano
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H251-H261
The question of the extent to which cytosolic Ca2+ affects sinoatrial node pacemaker activity has been discussed for decades. We examined this issue by analyzing two mathematical pacemaker models, based on the “Ca2+ clock” (C) and “membrane clo
Publikováno v:
Biophysical Journal. 97:3086-3094
The action potential, once triggered in ventricular or atrial myocytes, automatically proceeds on its time course or is generated spontaneously in sinoatrial node pacemaker cells. It is induced by complex interactions among such cellular components a