Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells

Autor: Eun Seo Bae, Woong Sub Byun, Chae Won Ock, Won Kyung Kim, Hyen Joo Park, Sang Kook Lee

Publikováno v: Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114039- (2023)

Although gemcitabine-based chemotherapy is common and effective for pancreatic cancer (PC), acquired drug resistance is one of the major reasons for treatment failure. Therefore, a novel therapeutic approach for gemcitabine-resistant PC is required.

Externí odkaz: https://doaj.org/article/6972fbe1db6c41f6a0f583cb0f908de2

Abstract 2787: Targeting Nrf2 signaling pathway by Keap1-mediated degradation in acquired gemcitabine resistant pancreatic cancer cells

Autor: Sang Kook Lee, Eun Seo Bae, Woong Sub Byun, Chae Won Ock, Won Kyung Kim, Hyen Joo Park

Publikováno v: Cancer Research. 83:2787-2787

Redox status is a main indicator of cancer cell adaptation to chemotherapy. Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the crucial regulators of redox condition and can affected to drug resistance through redox imbalance. The incide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2404db3ce10e08ff06dcb5543da98115
https://doi.org/10.1158/1538-7445.am2023-2787

Dioscin Decreases Breast Cancer Stem-like Cell Proliferation via Cell Cycle Arrest by Modulating p38 Mitogen-activated Protein Kinase and AKT/mTOR Signaling Pathways.

Autor: Chae WO; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, Korea.; Department of Food and Nutrition, Kyungnam University, Changwon, Korea., Kim GD; Department of Food and Nutrition, Kyungnam University, Changwon, Korea.

Publikováno v: Journal of cancer prevention [J Cancer Prev] 2021 Sep 30; Vol. 26 (3), pp. 183-194.