Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chae Janeka Reed"'
Autor:
Shan Chung, Dimitry M. Danilenko, Dongwei Li, Andrew Polson, Jacqueline McBride, Bing Zheng, Randall C. Dere, Marna Williams, Chae Janeka Reed, William R. Mathews, Saileta Prabhu, Caroline Looney, Kirsten Achilles Poon, Franklin Fuh
Publikováno v:
British Journal of Pharmacology. 174:628-640
SummaryBackground and purpose CD22 and CD79b are cell-surface receptors expressed on B-cell-derived malignancies such as non-Hodgkin's lymphoma (NHL). An anti-mitotic agent monomethyl auristatin E was conjugated to anti-CD22 and anti-CD79b antibodies
Autor:
Chae Janeka Reed, Jeff Lutman, Darren Brown, Robert Bayer, Shan Chung, Anne Wong, Eric Stefanich, Marcella Yu, Jean-Philippe Stephan
Publikováno v:
mAbs. 4:475-487
The effector functions of therapeutic antibodies are strongly affected by the specific glycans added to the Fc domain during post-translational processing. Antibodies bearing high levels of N-linked mannose-5 glycan (Man5) have been reported to exhib
Autor:
Xiaoying Gao, Wendy Lau, An Song, Martin Vanderlaan, Amy Shen, Linda Lin, Chris B Fong, Valerie Quarmby, Shan Chung, Yong Ying, Zhihua J. Qiu, Chae Janeka Reed
Publikováno v:
mAbs. 4:326-340
The presence or absence of core fucose in the Fc region N-linked glycans of antibodies affects their binding affinity toward FcγRIIIa as well as their antibody-dependent cell-mediated cytotoxicity (ADCC) activity. However, the quantitative nature of
Autor:
Jeff Lutman, Allen Nguyen, Chae Janeka Reed, Zhihua Julia Qiu, Anan Chuntharapai, Judy Young, Jane L. Grogan, Xiaoying Gao, Laura DeForge, Rong Deng, Yong Ying, Wai Lee Wong
Publikováno v:
Journal of immunological methods. 424
During drug development, measurement of suitable pharmacodynamic biomarkers is key to establishing in vivo drug activity. Binding of monoclonal antibody (mAb) therapeutics to soluble target proteins often results in elevated serum levels of their tar
Autor:
Shan Chung, Zhi-jie Jey Cheng, An Song, Valerie Quarmby, Yuwen L. Lin, Chae Janeka Reed, Fabio Malavasi, Carl Ng, Jihong Yang
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action implicated in the clinical efficacy of several therapeutic antibodies. In vitro ADCC assays employing effector cells capable of inducing lysis of target cells bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e799145e95a6eebb00c35ad367d38f3d
http://hdl.handle.net/2318/157797
http://hdl.handle.net/2318/157797
Autor:
Ron Firestein, Mccutcheon Krista, Jennifer Arca, Elizabeth Luis, Chae Janeka Reed, Suzanna Clark, Janet Tien, Paul Polakis, Ronald E. Ferrando, Jyoti Asundi
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(5)
Purpose: To identify and evaluate targets amenable to antibody therapy in melanoma. Experimental Design: We searched for mRNA transcripts coding for cell-surface proteins with expression patterns similar to that of the melanoma oncogene MITF. One suc