Transgelin 2 guards T cell lipid metabolism and antitumour function.

Autor: Hwang SM; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Awasthi D; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Jeong J; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sandoval TA; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Chae CS; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Research Institute, National Cancer Center, Goyang, Republic of Korea., Ramos Y; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA., Tan C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Marin Falco M; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Salvagno C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Emmanuelli A; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., McBain IT; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Mishra B; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA., Ivashkiv LB; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA., Zamarin D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cantillo E; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Chapman-Davis E; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Holcomb K; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Morales DK; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA., Yu X; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Conejo-Garcia JR; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke School of Medicine, Durham, NC, USA., Kaczocha M; Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, USA.; Stony Brook University Pain and Analgesia Research Center (SPARC), Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Vähärautio A; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Foundation for the Finnish Cancer Institute, Helsinki, Finland., Song M; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Departments of Integrative Biotechnology and of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, Republic of Korea., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA. jur2016@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. jur2016@med.cornell.edu.; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. jur2016@med.cornell.edu.

Publikováno v: Nature [Nature] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.

High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils.

Autor: Emmanuelli A; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Salvagno C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Hwang SM; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Awasthi D; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Sandoval TA; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Chae CS; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Cheong JG; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA., Tan C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Iwawaki T; Division of Cell Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan., Cubillos-Ruiz JR; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Publikováno v: Oncoimmunology [Oncoimmunology] 2024 Oct 02; Vol. 13 (1), pp. 2411070. Date of Electronic Publication: 2024 Oct 02 (Print Publication: 2024).

Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function.

Autor: Hwang SM; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Awasthi D; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Jeong J; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Sandoval TA; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Chae CS; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Ramos Y; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA., Tan C; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Falco MM; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., McBain IT; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA., Mishra B; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA., Ivashkiv LB; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA., Zamarin D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cantillo E; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Chapman-Davis E; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Holcomb K; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Morales DK; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute. Tampa, FL, USA., Conejo-Garcia JR; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA.; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Kaczocha M; Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, USA.; Stony Brook University Pain and Analgesia Research Center (SPARC), Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Vähärautio A; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Foundation for the Finnish Cancer Institute, Helsinki, Finland., Song M; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.

Publikováno v: Research square [Res Sq] 2023 Dec 14. Date of Electronic Publication: 2023 Dec 14.

Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.

Autor: Crowley MJP; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Bhinder B; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Markowitz GJ; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, 525 East 68th street, New York, NYk, 10065, USA., Martin M; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Verma A; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Volastra Therapeutics, New York, NY, 10027, USA., Sandoval TA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Chae CS; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Yomtoubian S; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Salk Institute for Biological Studies, San Diego, CA, USA., Hu Y; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Chopra S; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Vertex Ventures HC, 345 California Avenue, Palo Alto, CA, 94306, USA., Tavarez DA; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, NY, 10591, USA., Giovanelli P; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Gao D; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, 525 East 68th street, New York, NYk, 10065, USA., McGraw TE; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; Department of Biochemistry, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA., Altorki NK; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA., Elemento O; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA.; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA., Cubillos-Ruiz JR; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA. jur@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA. jur@med.cornell.edu.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA. jur@med.cornell.edu.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA. jur@med.cornell.edu., Mittal V; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA. vim2010@med.cornell.edu.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA. vim2010@med.cornell.edu.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 525 East 68th street, New York, NY, 10065, USA. vim2010@med.cornell.edu.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA. vim2010@med.cornell.edu.; Department of Cell and Developmental Biology, Weill Cornell Medicine, 525 East 68th street, New York, NYk, 10065, USA. vim2010@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th street, New York, NY, 10065, USA. vim2010@med.cornell.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 09; Vol. 14 (1), pp. 120. Date of Electronic Publication: 2023 Jan 09.

High-Fat Diet-Induced Obesity Alters Dendritic Cell Homeostasis by Enhancing Mitochondrial Fatty Acid Oxidation.

Autor: Chen IC; Department of Medicine, Weill Cornell Medicine, New York, NY.; Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan., Awasthi D; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY., Hsu CL; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Song M; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY.; Department of Integrative Biotechnology and Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, Gyeonggi-do, Korea; and., Chae CS; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY., Dannenberg AJ; Department of Medicine, Weill Cornell Medicine, New York, NY., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY; jur2016@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY.; Weill Cornell Graduate School of Medical Sciences, Cornell University. New York, NY.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Jul 01; Vol. 209 (1), pp. 69-76. Date of Electronic Publication: 2022 Jun 13.