Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Chady H Hakim"'
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198893 (2018)
BACKGROUND AND OBJECTIVE:Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) have become common for human gait analysis. Canines are important large animal models fo
Externí odkaz:
https://doaj.org/article/b6d506028dba4de6841706b0fe11b119
Autor:
Chady H Hakim, Alex Mijailovic, Thais B Lessa, Joan R Coates, Carmen Shin, Seward B Rutkove, Dongsheng Duan
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173557 (2017)
Dystrophin-deficient dogs are by far the best available large animal models for Duchenne muscular dystrophy (DMD), the most common lethal childhood muscle degenerative disease. The use of the canine DMD model in basic disease mechanism research and t
Externí odkaz:
https://doaj.org/article/d0e957bff0ce4e5e9dda60850711d79c
Autor:
Chady H Hakim, Yongping Yue, Jin-Hong Shin, Regina R Williams, Keqing Zhang, Bruce F Smith, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
The muscular dystrophies are a group of devastating genetic disorders that affect both skeletal and cardiac muscle. An effective gene therapy for these diseases requires bodywide muscle delivery. Tyrosine mutant adeno-associated virus (AAV) has been
Externí odkaz:
https://doaj.org/article/f79b056957d54f838f7f80c5a73f5adf
Autor:
Jian Liu, Lindsay M Wallace, Sara E Garwick-Coppens, Darcée D Sloboda, Carol S Davis, Chady H Hakim, Michael A Hauser, Susan V Brooks, Jerry R Mendell, Scott Q Harper
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Recent progress suggests gene therapy may one day be an option for treating some forms of limb girdle muscular dystrophy (LGMD). Nevertheless, approaches targeting LGMD have so far focused on gene replacement strategies for recessive forms of the dis
Externí odkaz:
https://doaj.org/article/5db5d515c3184e93891c54da638d9a3b
Autor:
Kasun Kodippili, Chady H. Hakim, Matthew J. Burke, Yongping Yue, James A. Teixeira, Keqing Zhang, Gang Yao, Gopal J. Babu, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101268- (2024)
Excessive cytosolic calcium accumulation contributes to muscle degeneration in Duchenne muscular dystrophy (DMD). Sarco/endoplasmic reticulum calcium ATPase (SERCA) is a sarcoplasmic reticulum (SR) calcium pump that actively transports calcium from t
Externí odkaz:
https://doaj.org/article/8999a19b16ac45ccb94ac3fd43620ab2
Autor:
Jin-Hong Shin, Brian Greer, Chady H Hakim, Zhongna Zhou, Yu-chia Chung, Ye Duan, Zhihai He, Dongsheng Duan
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59875 (2013)
The dystrophin-deficient dog is excellent large animal model for testing novel therapeutic modalities for Duchenne muscular dystrophy (DMD). Despite well-documented descriptions of dystrophic symptoms in these dogs, very few quantitative studies have
Externí odkaz:
https://doaj.org/article/c46755e925604bb887ac9a7962a3fd8b
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44438 (2012)
Loss of muscle force is a salient feature of Duchenne muscular dystrophy (DMD), a fatal disease caused by dystrophin deficiency. Assessment of force production from a single intact muscle has been considered as the gold standard for studying physiolo
Externí odkaz:
https://doaj.org/article/b43d911e66d14bf0bb08f0543eb967fc
Autor:
Chady H. Hakim, Sandeep R. P. Kumar, Dennis O. Pérez-López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi-jie Chen, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Cas9-specific T cell response has been speculated to impair CRISPR therapy. Here, the authors show that local and systemic AAV CRISPR therapy induces cytotoxic killing and eliminates rescued dystrophin in canine models of Duchenne muscular dystro
Externí odkaz:
https://doaj.org/article/fa789cec57864e868cf64db8cae359c5
Autor:
Jessica S. Fortin, Chady H. Hakim, Scott Korte, N. Nora Yang, Scott D. Fitzgerald, Gayle C. Johnson, Bruce F. Smith, Dongsheng Duan
Publikováno v:
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
Abstract The University of Missouri (MU) has established a colony of dystrophin‐deficient dogs with a mixed breed background to mirror the variable pathologic effects of dystrophinopathies between persons of a given kindred to further the understan
Externí odkaz:
https://doaj.org/article/351578939fd147a5a0fbbf1e34e6eb7d
Autor:
Chady H. Hakim, Hsiao T. Yang, Matthew J. Burke, James Teixeira, Gregory J. Jenkins, N. Nora Yang, Gang Yao, Dongsheng Duan
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Aged dystrophin-null canines are excellent models for studying experimental therapies for Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. To establish the baseline, we studied the extensor carpi ulnaris (ECU) mus
Externí odkaz:
https://doaj.org/article/f1538e91b7024c3397c00238eaa469ae