Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Chady H, Hakim"'
Autor:
Kasun Kodippili, Chady H. Hakim, Matthew J. Burke, Yongping Yue, James A. Teixeira, Keqing Zhang, Gang Yao, Gopal J. Babu, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101268- (2024)
Excessive cytosolic calcium accumulation contributes to muscle degeneration in Duchenne muscular dystrophy (DMD). Sarco/endoplasmic reticulum calcium ATPase (SERCA) is a sarcoplasmic reticulum (SR) calcium pump that actively transports calcium from t
Externí odkaz:
https://doaj.org/article/8999a19b16ac45ccb94ac3fd43620ab2
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract This study aims to develop a 4-limb canine gait analysis system using wireless inertial measurement units (IMUs). 3D printed sensor holders were designed to ensure quick and consistent sensor mounting. Signal analysis algorithms were develop
Externí odkaz:
https://doaj.org/article/8085843b0c4a4925b18a98e8db2ea7ae
Autor:
Chady H. Hakim, Sandeep R. P. Kumar, Dennis O. Pérez-López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi-jie Chen, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Cas9-specific T cell response has been speculated to impair CRISPR therapy. Here, the authors show that local and systemic AAV CRISPR therapy induces cytotoxic killing and eliminates rescued dystrophin in canine models of Duchenne muscular dystro
Externí odkaz:
https://doaj.org/article/fa789cec57864e868cf64db8cae359c5
Autor:
Jessica S. Fortin, Chady H. Hakim, Scott Korte, N. Nora Yang, Scott D. Fitzgerald, Gayle C. Johnson, Bruce F. Smith, Dongsheng Duan
Publikováno v:
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
Abstract The University of Missouri (MU) has established a colony of dystrophin‐deficient dogs with a mixed breed background to mirror the variable pathologic effects of dystrophinopathies between persons of a given kindred to further the understan
Externí odkaz:
https://doaj.org/article/351578939fd147a5a0fbbf1e34e6eb7d
Autor:
Chady H. Hakim, Nathalie Clément, Lakmini P. Wasala, Hsiao T. Yang, Yongping Yue, Keqing Zhang, Kasun Kodippili, Laura Adamson-Small, Xiufang Pan, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Barry J. Byrne, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 664-678 (2020)
Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene therapy. Many scalable manufacturing methods have been developed. However, the potency of the vectors generated by these methods has rarely been compared with
Externí odkaz:
https://doaj.org/article/c9a8a753dbc949b9af502c5c8edc3335
Autor:
Chady H. Hakim, Hsiao T. Yang, Matthew J. Burke, James Teixeira, Gregory J. Jenkins, N. Nora Yang, Gang Yao, Dongsheng Duan
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Aged dystrophin-null canines are excellent models for studying experimental therapies for Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. To establish the baseline, we studied the extensor carpi ulnaris (ECU) mus
Externí odkaz:
https://doaj.org/article/f1538e91b7024c3397c00238eaa469ae
Autor:
Chady H. Hakim, Nalinda B. Wasala, Xiufang Pan, Kasun Kodippili, Yongping Yue, Keqing Zhang, Gang Yao, Brittney Haffner, Sean X. Duan, Julian Ramos, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 216-230 (2017)
Micro-dystrophins are highly promising candidates for treating Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. Here, we report robust disease rescue in the severe DBA/2J-mdx model with a neuronal nitric oxide syn
Externí odkaz:
https://doaj.org/article/a968d82e3a484f8cb6cd48ebc8ad7bec
Autor:
Nalinda B. Wasala, Emily D. Million, Thais B. Watkins, Lakmini P. Wasala, Jin Han, Yongping Yue, Baisong Lu, Shi-jie Chen, Chady H. Hakim, Dongsheng Duan
Publikováno v:
Hum Gene Ther
Adeno-associated virus (AAV)-mediated clustered regularly interspaced short palindromic repeats (CRISPR) editing holds promise to restore missing dystrophin in Duchenne muscular dystrophy (DMD). Intramuscular coinjection of CRISPR-associated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bae538125f53cedcdc205fb649074e
https://doi.org/10.1089/hum.2021.130
https://doi.org/10.1089/hum.2021.130
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198893 (2018)
BACKGROUND AND OBJECTIVE:Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) have become common for human gait analysis. Canines are important large animal models fo
Externí odkaz:
https://doaj.org/article/b6d506028dba4de6841706b0fe11b119
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 3, Pp 195-213 (2015)
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly promising therapeutic strategy is to replace or repair the defective
Externí odkaz:
https://doaj.org/article/e4bc73bf374343ccb8c9d259858dea64