Inhibition of proline-rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.

Autor: Erkens R; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Duse DA; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Brum A; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Chadt A; Institute for Clinical Biochemistry and Pathobiochemistry, Deutsches Diabetes Zentrum at Heinrich Heine University of Duesseldorf, Duesseldorf, Germany.; German Center for Diabetes Research (DZD e.V.), Partner Duesseldorf, Neuherberg, Germany., Becher S; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Siragusa M; Center for Molecular Medicine, Institute for Vascular Signalling, Goethe University Frankfurt, Frankfurt, Germany.; German Centre for Cardiovascular Research, Partner site RhineMain, Frankfurt, Germany., Quast C; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Müssig J; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Roden M; German Center for Diabetes Research (DZD e.V.), Partner Duesseldorf, Neuherberg, Germany.; Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University and University Hospital Duesseldorf, Duesseldorf, Germany.; Institute for Clinical Diabetology, Deutsches Diabetes Zentrum at Heinrich Heine University of Duesseldorf, Duesseldorf, Germany., Cortese-Krott M; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.; CARID Cardiovascular Research Institute Duesseldorf, Duesseldorf, Germany., Ibáñez B; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Lammert E; German Center for Diabetes Research (DZD e.V.), Partner Duesseldorf, Neuherberg, Germany.; Institute of Metabolic Physiology, Heinrich-Heine University, Duesseldorf, Germany., Fleming I; Center for Molecular Medicine, Institute for Vascular Signalling, Goethe University Frankfurt, Frankfurt, Germany.; German Centre for Cardiovascular Research, Partner site RhineMain, Frankfurt, Germany., Jung C; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Al-Hasani H; Institute for Clinical Biochemistry and Pathobiochemistry, Deutsches Diabetes Zentrum at Heinrich Heine University of Duesseldorf, Duesseldorf, Germany.; German Center for Diabetes Research (DZD e.V.), Partner Duesseldorf, Neuherberg, Germany., Heusch G; Institute for Pathophysiology, West German Heart and Vascular Center, University School of Medicine Essen, Essen, Germany., Kelm M; Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.; CARID Cardiovascular Research Institute Duesseldorf, Duesseldorf, Germany.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Nov; Vol. 181 (21), pp. 4174-4194. Date of Electronic Publication: 2024 Jul 02.

Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion

Autor: C. Binsch, D. M. Barbosa, G. Hansen-Dille, M. Hubert, S. M. Hodge, M. Kolasa, K. Jeruschke, J. Weiß, C. Springer, S. Gorressen, J. W. Fischer, M. Lienhard, R. Herwig, S. Börno, B. Timmermann, A. L. Cremer, H. Backes, A. Chadt, H. Al-Hasani

Publikováno v: Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-14 (2023)

Abstract Background Type 2 Diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease and associated with poor outcome after myocardial infarction (MI). In T2DM, cardiac metabolic flexibility, i.e. the switch between carbohydrates and

Externí odkaz: https://doaj.org/article/1aa009e1fee843359a7e115e04fb7872

Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse

Autor: Inka Rapöhn, Ivet Elias, Juliane Weiner, Anna Pujol, Stephanie Kehr, Alexandra Chadt, Hadi Al-Hasani, Ralph Burkhardt, Nora Klöting, Michael Stumvoll, Fatima Bosch, Peter Kovacs, John T. Heiker, Jana Breitfeld

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

Adipose tissue inflammation and insulin resistance are hallmarks in the development of metabolic diseases resulting from overweight and obesity, such as type 2 diabetes and non-alcoholic fatty liver disease. In obesity, adipocytes predominantly secre

Externí odkaz: https://doaj.org/article/f7e50b71dc074a71be474ae2dec1aff1

A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium.

Autor: Geiser, Angéline, Currie, Susan, Al-Hasani, Hadi, Chadt, Alexandra, McConnell, Gail, Gould, Gwyn W.

Publikováno v: Journal of Cell Science; Oct2024, Vol. 137 Issue 20, p1-12, 12p

Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise

Autor: Anna Rita Minafra, Alexandra Chadt, Puyan Rafii, Hadi Al-Hasani, Kristina Behnke, Jürgen Scheller

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

High level of interleukin 6 (IL-6), released by adipocytes in an obesity-induced, low grade inflammation state, is a regulator of insulin resistance and glucose tolerance. IL-6 has also regenerative, anti-inflammatory and anti-diabetogenic functions,

Externí odkaz: https://doaj.org/article/8bd209574140489582ca3c78868f9e4c