Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chad W Euler"'
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006726 (2018)
A fundamental question in human susceptibility to bacterial infections is to what extent variability is a function of differences in the pathogen species or in individual humans. To focus on the pathogen species, we compared in the same individual th
Externí odkaz:
https://doaj.org/article/04d54df2f7e34177831ff53ea0d92cbb
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169180 (2017)
Streptococcus suis infects pigs worldwide and may be zoonotically transmitted to humans with a mortality rate of up to 20%. S. suis has been shown to develop in vitro resistance to the two leading drugs of choice, penicillin and gentamicin. Because o
Externí odkaz:
https://doaj.org/article/584db489c53d44668c9e774fe48e82ea
Autor:
Chad W Euler, Barbara Juncosa, Patricia A Ryan, Douglas R Deutsch, W Michael McShan, Vincent A Fischetti
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146408 (2016)
Streptococcus pyogenes is a human commensal and a bacterial pathogen responsible for a wide variety of human diseases differing in symptoms, severity, and tissue tropism. The completed genome sequences of >37 strains of S. pyogenes, representing dive
Externí odkaz:
https://doaj.org/article/690164f67df54a7d895280ef980fba45
Autor:
Christina Hendrickson, Chad W Euler, Scott V Nguyen, Maliha Rahman, Kimberly A McCullor, Catherine J King, Vincent A Fischetti, W Michael McShan
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145884 (2015)
Streptococcus pyogenes chromosomal island M1 (SpyCIM1) integrates by site-specific recombination into the 5' end of DNA mismatch repair (MMR) gene mutL in strain SF370SmR, blocking transcription of it and the downstream operon genes. During exponenti
Externí odkaz:
https://doaj.org/article/b555d625ff834545909ef32faff55db3
Autor:
Raymond Schuch, Adam J Pelzek, Assaf Raz, Chad W Euler, Patricia A Ryan, Benjamin Y Winer, Andrew Farnsworth, Shyam S Bhaskaran, C Erec Stebbins, Yong Xu, Adrienne Clifford, David J Bearss, Hariprasad Vankayalapati, Allan R Goldberg, Vincent A Fischetti
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60754 (2013)
We identified an essential cell wall biosynthetic enzyme in Bacillus anthracis and an inhibitor thereof to which the organism did not spontaneously evolve measurable resistance. This work is based on the exquisite binding specificity of bacteriophage
Externí odkaz:
https://doaj.org/article/015c5a7ce12a44dcbf5cce9c5e2c60a7
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 7, p e132 (2007)
Bacteria-host interactions are dynamic processes, and understanding transcriptional responses that directly or indirectly regulate the expression of genes involved in initial infection stages would illuminate the molecular events that result in host
Externí odkaz:
https://doaj.org/article/4f2c9c3113d84d26a3562f9573c8c860
Autor:
Rachael E. Workman, Marie J. Stoltzfus, Nicholas C. Keith, Chad W. Euler, Joseph Bondy-Denomy, Joshua W. Modell
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113849- (2024)
Summary: CRISPR-Cas immune systems provide bacteria with adaptive immunity against bacteriophages, but they are often transcriptionally repressed to mitigate auto-immunity. In some cases, CRISPR-Cas expression increases in response to a phage infecti
Externí odkaz:
https://doaj.org/article/8f1d1d1e943a4010b6fec27b0be2675a
Autor:
Chad W. Euler, Assaf Raz, Anaise Hernandez, Anna Serrano, Siyue Xu, Martin Andersson, Geng Zou, Yue Zhang, Vincent A. Fischetti, Jinquan Li
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Klebsiella pneumoniae and Pseudomonas aeruginosa are two leading causes of burn and wound infections, pneumonia, urinary tract infections, and more severe invasive diseases, which are often multidrug resistant (MDR) or extensively drug resistant. Due
Autor:
Pascal Maguin, Albina Kozlova, Jessica Fyodorova, Edmondo Campisi, Andrew Varble, Jakob T. Rostøl, Vincent A. Fischetti, Chad W. Euler, Luciano A. Marraffini
Publikováno v:
Nature Microbiology. 6:1516-1525
CRISPR loci are composed of short DNA repeats separated by sequences, known as spacers, that match the genomes of invaders such as phages and plasmids. Spacers are transcribed and processed to generate RNA guides used by CRISPR-associated nucleases t
Autor:
Maria Pardos de la Gandara, Christopher E Cheleuitte-Nieves, Leslie Lynn Diaz, Chad W. Euler, Alejandra Gonzalez, Winrich A. Freiwald, Hermínia M de Lencastre, Alexander Tomasz
Publikováno v:
Comparative Medicine. 70:335-347
Lytic enzymes are novel antimicrobial agents that degrade bacterial cell walls, resulting in cell rupture and death. We tested one enzyme, the bacteriocin lysostaphin, for treatment of nonhuman primates (Macaca mulatta) with persistent methicillinres