Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chad R Irwin"'
Autor:
Kyle G Potts, Chad R Irwin, Nicole A Favis, Desmond B Pink, Krista M Vincent, John D Lewis, Ronald B Moore, Mary M Hitt, David H Evans
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 5, Pp 638-654 (2017)
Abstract Bladder cancer has a recurrence rate of up to 80% and many patients require multiple treatments that often fail, eventually leading to disease progression. In particular, standard of care for high‐grade disease, Bacillus Calmette–Guérin
Externí odkaz:
https://doaj.org/article/7a25d246a5d84cfdbca40ab0fd93b132
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84134 (2013)
Myxoma virus (MYXV) is one of many animal viruses that exhibit oncolytic properties in transformed human cells. Compared to orthopoxviruses like vaccinia (VACV), MYXV spreads inefficiently, which could compromise its use in treating tumors and their
Externí odkaz:
https://doaj.org/article/578ad31e6dd24b63a415599f0db5d082
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
The rapid growth of tumors depends upon elevated levels of dNTPs, and while dNTP concentrations are tightly regulated in normal cells, this control is often lost in transformed cells. This feature of cancer cells has been used to advantage to develop
Externí odkaz:
https://doaj.org/article/68347d7cb4d74573b5a94762cebe00e0
Publikováno v:
Biotechnology and Genetic Engineering Reviews. 34:107-121
The past few years have seen a rash of emerging viral diseases, including the Ebola crisis in West Africa, the pandemic spread of chikungunya, and the recent explosion of Zika in South America. Vaccination is the most reliable and cost-effective meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76060ef5821b9f5ffd25f0e7a555b380
https://doi.org/10.1080/02648725.2018.1471643
https://doi.org/10.1080/02648725.2018.1471643
Autor:
Desmond Pink, Nicole Favis, Krista Vincent, Mary M. Hitt, John D. Lewis, Chad R. Irwin, Kyle Potts, Ronald B. Moore, David H. Evans
Publikováno v:
EMBO Molecular Medicine
Bladder cancer has a recurrence rate of up to 80% and many patients require multiple treatments that often fail, eventually leading to disease progression. In particular, standard of care for high‐grade disease, Bacillus Calmette–Guerin (BCG), fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7746cd99cca79b24037622ed7d7e0a1a
https://doi.org/10.15252/emmm.201607296
https://doi.org/10.15252/emmm.201607296
Publikováno v:
Journal of Urology. 195
INTRODUCTION AND OBJECTIVES: Most Bladder Cancers (BCs) are diagnosed as non-muscle invasive, however with a recurrence rate of up to 80%, many patients require multiple treatment strategies that often fail. In particular, Bacillus Calmette-Guerin (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3040b70cf6fbd3a841b33535001aa192
https://doi.org/10.1016/j.juro.2016.02.2195
https://doi.org/10.1016/j.juro.2016.02.2195
Autor:
R. Mark L. Buller, Kristin Burles, Chad R. Irwin, David H. Evans, Robyn-Lee Burton, Jill Schriewer, Michele Barry
Publikováno v:
Virology.
Currently, little is known about the ankyrin/F-box protein B4. Here, we report that B4R-null viruses exhibited reduced plaque size in tissue culture, and decreased ability to spread, as assessed by multiple-step growth analysis. Electron microscopy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67789cacd1c41357d702ed0b8260704d
https://pubmed.ncbi.nlm.nih.gov/24889230
https://pubmed.ncbi.nlm.nih.gov/24889230
Publikováno v:
Molecular Therapy. 23:S168-S169
Our data indicate that the VACs have retained their replication proficiency and cytotoxicity in BCa cells despite deletions of these critical viral replication genes. In vivo replication is selective for the cancerous cells and generates an antitumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d721110604e60039816ed349826f8b37
Autor:
David H. Evans, Chad R. Irwin
Vaccinia virus (VACV) produces large plaques consisting of a rapidly expanding ring of infected cells surrounding a lytic core, whereas myxoma virus (MYXV) produces small plaques that resemble a focus of transformed cells. This is odd, because bioinf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a35dfefc9df00a0c0af01b17a7faa74
https://europepmc.org/articles/PMC3416311/
https://europepmc.org/articles/PMC3416311/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 890
Vaccinia virus DNA polymerase (VVpol) encodes a 3'-to-5' proofreading exonuclease that can degrade the ends of duplex DNA and expose single-stranded DNA tails. The reaction plays a critical role in promoting virus recombination in vivo because single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44d6efec86d69f8715a08a12df1214bd
https://pubmed.ncbi.nlm.nih.gov/22688759
https://pubmed.ncbi.nlm.nih.gov/22688759