Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Chad N. Hancock"'
Publikováno v:
Amino Acids
Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41653f917da180994e76a5aa6d6f1963
http://europepmc.org/articles/PMC4752965
http://europepmc.org/articles/PMC4752965
Publikováno v:
Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of review Proline metabolism impacts a number of regulatory targets in both animals and plants and is especially important in cancer. Glutamine, a related amino acid, is considered second in importance only to glucose as a substrate for tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9ee82b33990d720b1d98784b8eb784
https://doi.org/10.1097/mco.0000000000000121
https://doi.org/10.1097/mco.0000000000000121
Publikováno v:
Epigenetics
Recent research suggests that chromatin-modifying enzymes are metabolic sensors regulating gene expression. Epigenetics is linked to metabolomics in response to the cellular microenvironment. Specific metabolites involved in this sensing mechanism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c02529841473e45d20c1507c786c7c
https://doi.org/10.4161/epi.24042
https://doi.org/10.4161/epi.24042
Autor:
Teresa W.-M. Fan, Chad N. Hancock, Andrew N. Lane, Chi V. Dang, Anne Le, Wei Liu, James M. Phang
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8983-8988
In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates glutamine catabolism to fuel growth and proliferation of cancer cells through up-regulating glutaminase (GLS). Glutamine is converted to glutamate by GLS, entering t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ecf50e3b6db2284f60461c18aa344c
https://doi.org/10.1073/pnas.1203244109
https://doi.org/10.1073/pnas.1203244109
Autor:
Jung Ho Jun, Raymond Divelbiss, Dianne L. Newton, Luke H. Stockwin, Chad N. Hancock, Melinda G. Hollingshead, Bingnan Han, Sanjay V. Malhotra
Publikováno v:
Free Radical Biology and Medicine. 50:110-121
In this study, a Cu(2+) chelate of the novel thiosemicarbazone NSC 689534 was evaluated for in vitro and in vivo anti-cancer activity. Results demonstrated that NSC 689534 activity (low micromolar range) was enhanced four- to fivefold by copper chela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c96ff8d23acea8034027424a21ca553
https://doi.org/10.1016/j.freeradbiomed.2010.10.696
https://doi.org/10.1016/j.freeradbiomed.2010.10.696
Autor:
Chad N. Hancock, Luke H. Stockwin, Dianne L. Newton, Suzanne Borgel, Lawrence R. Phillips, Melinda G. Hollingshead, Sherry X. Yu, Tracy L. Wolfe
Publikováno v:
International Journal of Cancer. 127:2510-2519
The "Warburg effect," also termed aerobic glycolysis, describes the increased reliance of cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, there is continued interest in inhibitors of glycolysis as cancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097b01910313800497c30045a96bdfd2
https://doi.org/10.1002/ijc.25499
https://doi.org/10.1002/ijc.25499
Autor:
Michael A. Tainsky, Raymond R. Mattingly, Jonathan W. Wojtkowiak, Joshua T. Dilworth, Patricia A. Mathieu, Chad N. Hancock, John J. Reiners
Publikováno v:
Cancer Biology & Therapy. 7:1938-1946
Neurofibromatosis Type 1 (NF1) is characterized by the abnormal proliferation of neuroectodermal tissues and the development of certain malignancies, particularly neurofibromas, which may progress into malignant peripheral nerve sheath tumors (MPNSTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58c4f319795dfea2ced2cf894975ebe
https://doi.org/10.4161/cbt.7.12.6942
https://doi.org/10.4161/cbt.7.12.6942
Publikováno v:
Scientific Reports
The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline biosynthesis (PB) from glutamine. Here we show MYC increases the expression of the enzymes in PB at bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a505ef9aa9d292f4dd25c3e662223ccb
http://europepmc.org/articles/PMC4657043
http://europepmc.org/articles/PMC4657043
Publikováno v:
Medicinal Chemistry. 2:213-222
Extracellular signals regulate most of the body's physiological functions through the MAP kinase signaling pathways. These MAP kinase signaling pathways are normally under tight regulation such that activation and inactivation occurs only when needed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060377e3ec35bbd83ffb36300cd70683
https://doi.org/10.2174/157340606776056151
https://doi.org/10.2174/157340606776056151
Publikováno v:
Amino Acids
Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef15e8ef12c701e1a4ca8a356041a113
https://doi.org/10.1007/s00726-016-2184-5
https://doi.org/10.1007/s00726-016-2184-5