Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chad N. Hancock"'
Publikováno v:
Amino Acids
Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport cha
Publikováno v:
Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of review Proline metabolism impacts a number of regulatory targets in both animals and plants and is especially important in cancer. Glutamine, a related amino acid, is considered second in importance only to glucose as a substrate for tumor
Publikováno v:
Epigenetics
Recent research suggests that chromatin-modifying enzymes are metabolic sensors regulating gene expression. Epigenetics is linked to metabolomics in response to the cellular microenvironment. Specific metabolites involved in this sensing mechanism in
Autor:
Teresa W.-M. Fan, Chad N. Hancock, Andrew N. Lane, Chi V. Dang, Anne Le, Wei Liu, James M. Phang
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8983-8988
In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates glutamine catabolism to fuel growth and proliferation of cancer cells through up-regulating glutaminase (GLS). Glutamine is converted to glutamate by GLS, entering t
Autor:
Jung Ho Jun, Raymond Divelbiss, Dianne L. Newton, Luke H. Stockwin, Chad N. Hancock, Melinda G. Hollingshead, Bingnan Han, Sanjay V. Malhotra
Publikováno v:
Free Radical Biology and Medicine. 50:110-121
In this study, a Cu(2+) chelate of the novel thiosemicarbazone NSC 689534 was evaluated for in vitro and in vivo anti-cancer activity. Results demonstrated that NSC 689534 activity (low micromolar range) was enhanced four- to fivefold by copper chela
Autor:
Chad N. Hancock, Luke H. Stockwin, Dianne L. Newton, Suzanne Borgel, Lawrence R. Phillips, Melinda G. Hollingshead, Sherry X. Yu, Tracy L. Wolfe
Publikováno v:
International Journal of Cancer. 127:2510-2519
The "Warburg effect," also termed aerobic glycolysis, describes the increased reliance of cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, there is continued interest in inhibitors of glycolysis as cancer t
Autor:
Michael A. Tainsky, Raymond R. Mattingly, Jonathan W. Wojtkowiak, Joshua T. Dilworth, Patricia A. Mathieu, Chad N. Hancock, John J. Reiners
Publikováno v:
Cancer Biology & Therapy. 7:1938-1946
Neurofibromatosis Type 1 (NF1) is characterized by the abnormal proliferation of neuroectodermal tissues and the development of certain malignancies, particularly neurofibromas, which may progress into malignant peripheral nerve sheath tumors (MPNSTs
Publikováno v:
Scientific Reports
The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline biosynthesis (PB) from glutamine. Here we show MYC increases the expression of the enzymes in PB at bo
Publikováno v:
Medicinal Chemistry. 2:213-222
Extracellular signals regulate most of the body's physiological functions through the MAP kinase signaling pathways. These MAP kinase signaling pathways are normally under tight regulation such that activation and inactivation occurs only when needed
Publikováno v:
Amino Acids
Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport cha