Výsledky vyhledávání - "Chad M Warren"

Akademický článek

Altered coronary artery function, arteriogenesis and endothelial YAP signaling in postnatal hypertrophic cardiomyopathy

Autor: Paulina Langa, Richard J. Marszalek, Chad M. Warren, Shamim K. Chowdhury, Monika Halas, Ashley Batra, Koreena Rafael-Clyke, Angelie Bacon, Paul H. Goldspink, R. John Solaro, Beata M. Wolska

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Introduction: Hypertrophic cardiomyopathy (HCM) is a cardiovascular genetic disease caused largely by sarcomere protein mutations. Gaps in our understanding exist as to how maladaptive sarcomeric biophysical signals are transduced to intra- and extra

Externí odkaz: https://doaj.org/article/e99641809e6e470d9ce61d862b63471e

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Akademický článek

Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes

Autor: Christopher Solís, Walter C. Thompson, James R. Peña, Christopher McDermott-Roe, Paulina Langa, Chad M. Warren, Magdalena Chrzanowska, Beata M. Wolska, R. John Solaro, Pieter Detombe, Paul H. Goldspink

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

In the heart, alternative splicing of the igf-I gene produces two isoforms: IGF-IEa and IGF-IEc, (Mechano-growth factor, MGF). The sequence divergence between their E-domain regions suggests differential isoform function. To define the biological act

Externí odkaz: https://doaj.org/article/4276e5406b9d47d2af2e397c632f998a

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Akademický článek

B-arrestin-2 Signaling Is Important to Preserve Cardiac Function During Aging

Autor: Andrielle E. Capote, Ashley Batra, Chad M. Warren, Shamim A. K. Chowdhury, Beata M. Wolska, R. John Solaro, Paola C. Rosas

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Experiments reported here tested the hypothesis that β-arrestin-2 is an important element in the preservation of cardiac function during aging. We tested this hypothesis by aging β-arrestin-2 knock-out (KO) mice, and wild-type equivalent (WT) to 12

Externí odkaz: https://doaj.org/article/dd5211b59a5f480daa17eb7fdc020ff5

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Akademický článek

Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction

Autor: Paola C. Rosas, MD, PhD, BSPharm, Chad M. Warren, MS, Heidi A. Creed, BS, Jerome P. Trzeciakowski, PhD, R. John Solaro, PhD, Carl W. Tong, MD, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 817-830 (2019)

Summary: Cardiac myosin binding protein-C (cMyBP-C) phosphorylation prevents aging-related cardiac dysfunction. We tested this hypothesis by aging genetic mouse models of hypophosphorylated cMyBP-C, wild-type equivalent, and phosphorylated-mimetic cM

Externí odkaz: https://doaj.org/article/3f0f466b8a174049852691b9fb177b8e

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Akademický článek

Western Diet-Fed, Aortic-Banded Ossabaw Swine

Publikováno v: JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 404-421 (2019)

Summary: The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet−fed,

Externí odkaz: https://doaj.org/article/234f0de86b414fc8be6239d78aedf7cf

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Akademický článek

Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response

Autor: Shamim A. K. Chowdhury, Chad M. Warren, Jillian N. Simon, David M. Ryba, Ashley Batra, Peter Varga, Evangelia G. Kranias, Jil C. Tardiff, R. John Solaro, Beata M. Wolska

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a “disease of the sarcomere.” Despite the discovery of sarcomere protein mutations linked to

Externí odkaz: https://doaj.org/article/4f5f102bf0564eda9c95446b3789c405

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Abstract P1058: Whole-cell Mechanical Loading And Unloading Triggers More Post-translational Modifications In α-actinin Than Myosin Activators And Inhibitors

Autor: Christopher Solis, Elisabeth DiNello, Chad M Warren, Kyle Dittloff, R John Solaro, Brenda Russell

Publikováno v: Circulation Research. 131

The hypothesis tested is that unloading of mechanical forces affects acetylation, ubiquitination, and phosphorylation of the actin-binding protein α-actinin located in the Z-disc. We applied targeted proteomics to interrogate the post-translational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::719eae54ff869e513767b6b3d80e0932
https://doi.org/10.1161/res.131.suppl_1.p1058

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Abstract 11855: Disruption of β-arrestin-2 Signaling Resulted in Impaired Systolic and Diastolic Function During Aging

Autor: Paola C Rosas, Andrielle E Capote, Chad M Warren, Shamim Chowdhury, Beata M Wolska, R J Solaro

Publikováno v: Circulation. 144

Introduction: Angiotensin II (ang II) signaling at ang II receptor type 1 (AT1R), which is a G-protein coupled receptor (GPCR), promotes both G-protein signaling as well as β-arrestin-2 signaling. β-arrestin-2 participates in GPCR desensitization,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebc5148584a70d7a4bdec29a5cd89e5c
https://doi.org/10.1161/circ.144.suppl_1.11855

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